Abstract

摘要： 新生儿缺氧性肺动脉高压(hypoxia-induced pulmonary hypertension of the newborn，HPH)的发生涉及很多方面，肺血管收缩反应增强和肺血管结构重建是肺动脉高压形成的血管变化特征。而目前HPH的发病机制仍不清楚，但近年来研究表明缺氧诱导因子-1α(hypoxia inducible factor，HIF-1α)及其诱导因子内皮素-1(endothelia -1，ET-1)、促红细胞生成素(erythropoietin，EPO)及血管内皮生长因子(vascular Endothelia factor，VEGF)在肺动脉高压的发生、发展中发挥重要作用。本文将对HIF-1α、ET-1、EPO、VEGF在新生儿低氧性肺动脉高压发病中的重要作用及其进展进行简要概述。

关键词: 低氧性肺动脉高压, 缺氧诱导因子-1α, 内皮素-1、促红细胞生成素, 血管内皮生长因子

CLC Number:

R722.1

徐焕丽，陈敬国. 新生儿缺氧性肺动脉高压发病机制的研究进展[J]. 中国儿童保健杂志, 2014, 22(10): 1058-1061.

References

[1] 金汉珍,黄德珉,官希吉.实用新生儿学[M].3版.北京:人民卫生出版社,2002:177-179.
[2] Rabinovitch M.Molecular pathogenesis of pulmonary arterial hypertension[J].J Clin Invest,2008,118:2372-2379.
[3] Galiè N,Hoeper MM,Humbert M,et al.Guidelines for the diagnosis and treatment of pulmonary hypertension[J].Euro Heart,2009,30(20):2493-2537.
[4] 薛守斌,王东,刘巍.缺氧诱导因子1与缺氧性肺动脉高压的研究进展[J].医学综述,2013,19(19):3474-3477.
[5] Pan P,Zhang X.Effects of electro-acupuncture on endothelium-derived endothelin-1 and endothelial nitric oxide syntheses of rats with hypoxia-induced pulmonary hypertension[J].Exp Boil Med(Maywood),2010,235(5):642-648.
[6] He ZH,Dai AG,Zhang XF,et al.Expressions of hypoxia inducible factor-1 and inducible nitric oxide synthesis gene in the development of hypoxia pulmonary hypertension in rats[J].Clin Rehab Tissue Eng Res,2007,11(36):7290-7294.
[7] 蔡彬梅,陈敬国.缺氧性肺动脉高压新生儿血清中HIF1-α、EPO和ET-1变化测定[J].国际医药卫生导报,2013,19(5):605-607.
[8] 王建荣,周英.缺氧性肺动脉高压新生大鼠肺血管重塑与肺血管HIF1-α、ET-1及iNOS的表达相关研究[J].中国当代儿科杂志,2013,15(2):138-144.
[9] Brussel Mans K,Compernoll EV,TJ WAM,et al.Heterozygous,deficiency of hypoxia-inducible factor-2 alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia[J].J Clin Invest,2009,111(10):1519-1527.
[10] Schiodler MB,Hislop AA,Haworth SG.Porcine pulmonary artery and bronchial responses to endothelin-1 and norepinephrine on recovery from hypoxic pulmonary hypertension[J].Pediatr Res,2006,60(1):71-76.
[11] 王姚爱敏,郝亚平.新生儿持续肺动脉高压患儿血浆心房利钠肽、内皮素-1及血管性假血友病因子的变化[J].中国当代儿科杂志,2013,15(9):718-722.
[12] 曹静,王红,李明霞.内皮素-1在缺氧性肺动脉高压新生儿大鼠肺组织中的表达变化及意义[J].中华实用儿科临床杂志,2013,28(20):1561-1565.
[13] Yan LD,Kong LL,Yong ZH,et al.Inhibition of endothelin-1 and hypoxia-induced pulmonary presser responses in the rat by a novel selective endothelia-A receptor antagonist,di-n-butylaminocarbamyl-L-leucyl-D-tryptophanyl-D-4-chloro-Phe[J].J Cardiovascular Pharmacol,2010,56(3):246-254.
[14] Yoshiko Y,Satoshi H,Takeshi H,et al.Erythropoietin-responsive sites in normal and malignant human lung tissues[J].Anant Sci Int,2010,85:204-213.
[15] Vaziri ND.Cardiovascular effects of erythropoietin and anemia correction[J].Curr Opin Nephrol Hypertens,2001,10:633-637.
[16] Wang L,Chopp M.Neural progenitor cells treated with EPO induce angiogenesis through the production of VEGF[J].J Cereb Blood Flow Metab,2008,28(7):1361-1368.
[17] Lebel M.Antihypertensive and renal protective effects of Renin-Angiotensin system blockade in uremic rats treated with erythropoietin[J].Am J Hypertens,2006,19:1286-1292.
[18] Cook KM,Figg WD.Angiogenesis' inhibitors:Current strategies and future prospects[J].Ca Cancer J Clin,2010,60(4):222-243.
[19] Bletsa A,Virtej A,Berggreen E.Vascular endothelial growth actors and receptors are up-regulated during development of apical periodontitis[J].J Endod,2012,38:628-635.
[20] Ferrara N.History of discovery:vascular endothelial growth factor[J].Arterioscler Thromb Vasc Biol,2009,29(1):22-24.
[21] Saini Y,Harkema R,LaPres JJ,et al.HIF-1α is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice[J].J Biol Chem,2008,283(48):33650-33657.
[22] Watts KD,McColley SA.Elevated vascular endothelial growth factor is correlated with elevated erythropoietin in stable,young cystic fibrosis patients[J].Pediatr Pulmonology,2011,46(7):683-687.
[23] Abman SH.Recent advances in the pathogenesis and treatment of persistent pulmonary hypertension of the newborn[J].Neonatology,2007,91(4):283-290.
[24] Schad JF,Mehzer KR,Hicks MR,et al.Cyclic strain up-regulates VEGF and attenuates proliferation of vascular smooth muscle cells[J].Vasc CelI,2011,3:21-30.

新生儿缺氧性肺动脉高压发病机制的研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	CUI Pengyuan, LI Guiping. Causal relationship between neonatalhy perbilirubinemia and tic disorder by Mendelian randomization [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1116-1121.
[2]	. [J]. Chinese Journal of Child Health Care, 2024, 32(9): 929-933.
[3]	WEI Ping, WEI Jishan, HUANG Xuhua, ZHANG Yuxing, LIU Xianghong, HE Zhongbiao, MO Jingyuan, HUANG Zengshuai, YU Qun. Application of cardiac auscultation, pulse oximetry combine with oxygen inhalation in screening neonatal congenital heart disease in Guangxi Province [J]. Chinese Journal of Child Health Care, 2024, 32(9): 1034-1039.
[4]	HUANG Wanyi, ZHANG Youxiang, OU Qiaoqun, LIU Yuanchun, GUO Jiayu. Effects of gestational diabetes mellitus on brain development and miRNAs expression profile in neonatal mice [J]. Chinese Journal of Child Health Care, 2024, 32(2): 154-158.
[5]	LU Anfeng, HUANG Peilu, BI Lei, HUANG Guosheng, HUANG Haiyan. Physical and neuropsychological development of the offspring born to mother with gestational diabetes mellitus at 2 years old [J]. Chinese Journal of Child Health Care, 2024, 32(2): 208-211.
[6]	WEI Jufang, CHEN Jijian. Trends and influencing factors of low birth weight of newborns in Xixiangtang District, Nanning City from 2015 to 2021 [J]. Chinese Journal of Child Health Care, 2023, 31(7): 785-789.
[7]	. [J]. Chinese Journal of Child Health Care, 2023, 31(2): 225-228.
[8]	CHEN Yu-xia, LIU Hua-yan, FAN Qian-qian. Changes of neuron specific enolase, transcutaneous hour bilirubin, total bilirubin/albumin levels in full-term infants with hyperbilirubinemia and their correlation with long-term neurodevelopment [J]. Chinese Journal of Child Health Care, 2023, 31(1): 86-90.
[9]	ZHANG Du-fei, ZHANG Xiang-yun. Epidemiological survey on neonatal congenital heart disease in Hainan Province in 2020 [J]. Chinese Journal of Child Health Care, 2023, 31(1): 91-95.
[10]	WANG Hui-ping, WANG Li, GAO Qiong, BAI Bo-liang, MA Ying-jun. Physical and neurological development of necrotizing enterocolitis in very low birth weight infants [J]. Chinese Journal of Child Health Care, 2023, 31(1): 96-100.
[11]	LIANG Li-yu, ZHU Hui. Prognosis of neonates with mild hyperthyrotropinemia [J]. Chinese Journal of Child Health Care, 2022, 30(12): 1409-1413.
[12]	LIANG Sui-xin, TI Yun-xing, HUANG Jun-rong, LI Xiu-hong, ZHOU Wen-jia. Protective effect and mechanism of delayed mild hypothermia on white matter injury inoxygen-glucose deprivation and restoration newborn rats [J]. Chinese Journal of Child Health Care, 2022, 30(10): 1083-1087.
[13]	LIU Jian-hong, HUANG Fang. Association of serum NFP and Nrf2 levels with early brain injury in neonatal asphyxia [J]. Chinese Journal of Child Health Care, 2022, 30(7): 787-791.
[14]	DONG Li-ping, ZHANG Zhen, CUI Yan-guo, LI Qing-bo. Application of screening indices for methylmalonic acidemia in Zibo city [J]. Chinese Journal of Child Health Care, 2022, 30(7): 792-795.
[15]	ZHOU Li-xia, CAI Dong, CHEN You-ping. Effect of melatonin regulating Akt/mTOR signal pathway on intestinal barrier function in neonatal rats with necrotizing enterocolitis [J]. Chinese Journal of Child Health Care, 2022, 30(6): 622-626.