Objective To explore the relationship between growth pattern from birth to preschool age and insulin resistance. Methods Fasting glucose, insulin, HOMA-IR and HOMA-β value in 68 small for gestaional age(SGA) infants and 42 appropriate for gestaional age(AGA) infants at age 3-day and 4-year were studied by a prospective study, and the relations with growth pattern were analyzed in 68 SGA infants. Results SGA infants had significantly higher fasting insulin concentration and HOMA-IR value than AGA infants at age 3-day and 4-year (P<0.05).No catch-up growth of weight in SGA infants had significantly higher fasting insulin concentration and HOMA-IR value than catch-up growth of weight in SGA infants(P<0.01).There was no significant difference in HOMA-β value among each groups (P>0.05). Conclusions SGA infants display insulin resistance from birth to preschool age.No catch-up growth of weight in SGA infants have higher insulin resistance.The function of β-cell of pancreatic islands has no remarkable change.
Key words
small for gestaional age infant /
insulin resistance /
growth pattern
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