doi:10.11852/zgetbjzz2014-22-06-20

Abstract

摘要： 磷脂酰肌醇3-激酶/蛋白激酶B(phosphoinositide 3-kinase/protein kinase B, PI3K/Akt)信号通路广泛存在于各种神经细胞中, 是膜受体信号向细胞内转导的重要途径, 具有调节细胞增殖、分化、代谢、抗细胞凋亡等细胞生物学作用。PI3K/Akt信号通路在自闭症中的作用逐渐引起学者重视, 目前多用于探讨发病机制、寻找诊断标记和研发治疗药物的研究。因此, 本文通过综述PI3K/Akt信号通路及其在自闭症的作用等方面的研究进展, 期待PI3K/Akt可以成为防治自闭症的新靶点。

关键词: PI3K/Akt信号通路, 脑, 自闭症

CLC Number:

R749.94

郑臻, 章小雷, 黄钢. PI3K/Akt信号通路与自闭症(孤独症)的研究进展[J]. 中国儿童保健杂志, 2014, 22(6): 623-626.

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PI3K/Akt信号通路与自闭症(孤独症)的研究进展

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