doi:10.11852/zgetbjzz2014-22-06-17

Abstract

摘要： 近年来的研究发现生命早期的叶酸营养状况对孤独症的发生有重要的影响, 表现为孕期叶酸摄入量不足后代孤独症发病风险增加, 围孕期叶酸补充可以降低那些叶酸代谢效率低下的孕妇生育孤独症患儿的风险, 表观遗传改变可能在其中起重要作用, 这为早期防治孤独症提供了新的思路, 即检测与叶酸代谢相关基因多态性以及与叶酸甲基化有关的蛋氨酸循环酶作为新生儿筛查的一部分, 可以确定哪些新生儿需要监测和补充叶酸, 以确保在生后神经发育关键时期的叶酸水平, 降低孤独症的发病风险。

关键词: 叶酸, 孤独症谱系障碍, 生命早期

CLC Number:

R749.94

衣明纪, 王薇, 李音. 生命早期叶酸营养状况与孤独症发病风险[J]. 中国儿童保健杂志, 2014, 22(6): 614-616.

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生命早期叶酸营养状况与孤独症发病风险

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