Research progress on the mechanism of perinatal depression′s impact on offspring neurofunctional development

doi:10.11852/zgetbjzz2024-1297

Abstract

Abstract: Early life is a critical period for neurodevelopment in children. Perinatal depression (PND) has been demonstrated to profoundly affect various aspects of offspring development, including motor skills, language, cognition, and social abilities. This article reviews the impact of PND on offspring neurofunctional development and its potential underlying mechanisms, such as epigenetic regulation, impaired mother-infant attachment, alterations in brain structure and function, hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, immune inflammation, abnormal gut microbiota, and multi-omics regulation. It also proposes preventive measures for PND, aiming to promote maternal mental health during the perinatal period and mitigate the negative effects of PND on offspring neurofunctional development.

Key words: perinatal depression, infants and young children, neurofunctional development, hypothalamic-pituitary-adrenal axis

摘要： 生命早期是儿童神经发育的关键时期。围产期抑郁(PND)已被证明会对子代的运动、语言、认知和社交等多方面产生深远影响。本文概述了PND对子代神经功能发育的影响及其可能的作用机制,如表观遗传调控、母婴依恋受损、大脑结构和功能受损、下丘脑-垂体-肾上腺(HPA)轴功能亢进、免疫炎症、肠道菌群异常以及多组学调控等,提出了PND的预防措施,旨在促进围生期母亲的心理健康,减轻PND对子代神经功能发育的负面影响。

关键词: 围产期抑郁, 婴幼儿, 神经功能发育, 下丘脑-垂体-肾上腺轴

CLC Number:

R179

ZHI Jincao, XU He, CHANG Qing, WU Shanhong, QIN Huan, WANG Yan. Research progress on the mechanism of perinatal depression′s impact on offspring neurofunctional development[J]. Chinese Journal of Child Health Care, 2025, 33(12): 1348-1352.

支金草, 徐河, 常庆, 吴珊红, 秦欢, 王艳. 围产期抑郁对子代神经功能发育影响机制的研究进展[J]. 中国儿童保健杂志, 2025, 33(12): 1348-1352.

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