Objective To investigate the relation between EOS and asthma;To evaluate the alteration and significance of serum IL-4 and IFN-γ in bronchial asthma. Methods Forced expiratory volume in one second (FEV1) was measured in all patients as a percent of predicted value; The use of ultrasonic inhalation of 3% to 5% hypertonic saline induced EOS percentage ;The serum levels of IL-4 and IFN-γ were measured by ELISA in 69 cases of asthma at stage of episode, and 42 cases healthy people. Results The levels of EOS and IL-4 in bronchial asthma patients were significantly higher than of normal control group (P=0.009;P=0.012);while the level of IFN-γ in bronchial asthma patients were significantly lower than of normal control group(P=0.020). Conclusion Augmentation of EOS, IL-4 and IFN-γ had close correlation with bronchial asthma, to improve the clinical diagnosis of asthma.
Key words
bronchial asthma /
eosinophil /
IL-4 /
IFN-γ
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