Objective To investigate the relationship between bisphenol-A(BPA) and precocious puberty in girls and study the relationship between life style and BPA exposure and precocious puberty first time. Methods 44 precocious girls as the case group and 44 normal girls as the control group were recruited from July to December in 2011.The concentrations of BPA in urine samples were measured by using high performance liquid chromatography (HPLC).The data of life style was learned through self made-up questionnaire. Results The positive rate of BPA in the case group (70.45%) was significantly higher than the control group (43.18%) (χ2=6.67,P<0.05).The concentrations of BPA in urine samples from the case group were significantly higher than samples from the control group,too (Z=3.49,P<0.01).The habit of hot water drinking from barreled water might be a week risk factor of precocious puberty in girls (β=0.967 8,χ2=3.870 3,P=0.049 1,OR=2.632,95%CI:1.004~6.903). Conclusions The exposure of BPA may be associated with the onset of precocious puberty in girls.The positive rate of BPA in the control group is high.Urine is considered to be the appropriate sample for BPA detection.The habit of hot water drinking from barreled water may slightly increase the risk of precocious puberty in girls.It's absolutely important to learn how to use plastics in the right way.
Key words
case-control study /
precocious puberty /
bisphenol-A /
life style
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