Abstract: Objective To investigate the relationship between bisphenol-A(BPA) and precocious puberty in girls and study the relationship between life style and BPA exposure and precocious puberty first time. Methods 44 precocious girls as the case group and 44 normal girls as the control group were recruited from July to December in 2011.The concentrations of BPA in urine samples were measured by using high performance liquid chromatography (HPLC).The data of life style was learned through self made-up questionnaire. Results The positive rate of BPA in the case group (70.45%) was significantly higher than the control group (43.18%) (χ²=6.67,P<0.05).The concentrations of BPA in urine samples from the case group were significantly higher than samples from the control group,too (Z=3.49,P<0.01).The habit of hot water drinking from barreled water might be a week risk factor of precocious puberty in girls (β=0.967 8,χ²=3.870 3,P=0.049 1,OR=2.632,95%CI:1.004~6.903). Conclusions The exposure of BPA may be associated with the onset of precocious puberty in girls.The positive rate of BPA in the control group is high.Urine is considered to be the appropriate sample for BPA detection.The habit of hot water drinking from barreled water may slightly increase the risk of precocious puberty in girls.It's absolutely important to learn how to use plastics in the right way.

Key words: case-control study, precocious puberty, bisphenol-A, life style

摘要： 目的 探讨双酚A与女童性早熟发病的关系;首次尝试了解生活习惯与双酚A暴露及性早熟的关系。方法 收集2011年7-12月于本院门诊就诊的性早熟病例组和正常对照组女童各44例;采用高效液相色谱法分别检测两组女童尿液双酚A浓度;通过自编问卷了解日常生活中可能存在双酚A暴露的生活习惯。结果 病例组和对照组尿液双酚A检出率分别为70.45%和43.18%,差异有统计学意义(χ²=6.67,P<0.05);病例组尿液双酚A浓度高于对照组(Z=3.49,P<0.01);是否饮用桶装水热水可能是女童患有性早熟的弱危险因素(β=0.967 8,χ²=3.870 3,P=0.049 1,OR=2.632,95%CI:1.004~6.903)。 结论 双酚A暴露可能与女童性早熟发病有关;正常对照组女童亦有较高的双酚A暴露率;尿样更适合用来评估人体双酚A暴露情况;常饮用桶装水热水可能增加女童患性早熟的风险;正确合理地使用塑料制品十分重要。

关键词: 病例对照研究, 性早熟, 双酚A, 生活习惯