Objective To observe the behavioral characteristics of animal models of spontaneously hypertensive rats (SHR) with attention deficit hyperactivity disorder (ADHD)on the behavior of the similarity. Methods 10 spontaneously hypertensive rats (SHR),Sprague Dawley rats (SD),Wistar Kyoto rats (WKY) rats in each.The panels the rats passed,the times of straighten and grooming,and times of dejecture were observed and recorded by using open-field environment test. Results The panels passed and the times of straightening SHR rats were significantly higher than those of the SD and WKY rats(P<0.01);the times of grooming and dejecture of SHR rats had no differences with the other groups(P>0.05). Conclusions SHR rats with significantly higher hyperactivity than SD WKY rats,could be a very good representation of hyperactivity behavior of characteristics,and be ideal animal models of ADHD.
Key words
attention deficit hyperactivity disorder /
spontaneously hypertensive rats /
Wistar Kyoto rats /
Sprague Dawley rats /
the open field test
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