Abstract: 【Objective】 To study the characteristic changes of multifocal VEP in strabismic and anisometropic amblyopes,and evaluate the mechanism of amblyopia. 【Methods】 The multifocal pattern VEP of both eyes of 30 strabismic amblyopes,31 anisometropic amblyopes and 30 normal subjects were recorded by VERIS ScienceTM4.2 multifocal visual evoked response imaging system made of America EDI company.The latencies and amplitudes of P waves were analysed.Changes were investigated by comparing the amblyopic eyes,the fellow eyes of the patients and the normal eyes. 【Results】 At six eccentricities the amplitudes of P waves of the amblyopic eyes were reduced and the latencies of P waves were markedly prolonged compared with the fellow eyes and the normal eyes.The mean amplitude of mVEP in the nasal retinal hemifields was smaller than in the temporal retinal hemifields in strabismic amblyopes. 【Conclusion】 Different types of amblyopia may have different neural mechanisms,the results suggest that multifocal VEP could be used in instructing the diagnosis and treatment of amblyopia.

Key words: strabismus, anisometropia, amblyopia, multifocal VEP

摘要： 【目的】 研究斜视性弱视与屈光参差性弱视患者弱视眼与对侧眼的多焦视觉诱发电位(multifocal visual evoked potential,mVEP)的特征性变化,探讨两种不同类型弱视的发病机理。【方法】 采用美国EDI公司生产的VERIS ScienceTM4.2多焦电生理系统对31例屈光参差性弱视患者、30例斜视性(内斜)弱视患者及30例正常人双眼分别进行图形mVEP检测,以潜伏期与振幅为分析指标,进行了屈光参差性弱视眼、对侧眼和正常对照三组mVEP的对比研究。【结果】 六个离心度上弱视眼反应振幅密度较其对侧眼和正常眼均显著降低,潜伏期延长(P＜0.01)。正常对照组及屈光参差性弱视组中鼻侧网膜与颞侧网膜反应振幅密度差异均无统计学意义,而斜视性(内斜)弱视组中,鼻侧网膜反应振幅密度均小于颞侧网膜。【结论】 不同类型弱视可能具有不同的神经机制,mVEP检查可为弱视的诊断、治疗和预后判断提供客观依据。

关键词: 斜视, 屈光参差, 弱视, 多焦视觉诱发电位