Abstract: 【Objective】 To investigate the level of arsenic (As) exposure during the fetal period in Shanghai,and analyze the relationship between neonatal physical growth indicators and arsenic levels in umbilical cord blood. 【Methods】 Umbilical cord blood samples were collected from pregnant women in Shanghai during October 2008 and October 2009.The arsenic levers in umbilical cord blood were measured by inductively coupled plasma emission mass spectroscopy (ICP-MS).The birth weight (BW),birth length (BL) and head circumference (HC) of the newborns delivered to the subjects were measured and the association of arsenic exposure with physical growth indicators was assessed by linear correlation analyses. 【Results】 291 umbilical cord blood were collected and measured,the maximum of total As was 24.87 μg/L,and the minimum was 1.81 μg/L,the geometric mean of total As in umbilical cord blood was (5.48±3.49) μg/L,Median was 5.42μg/L.In this range of exposure,there were no dose-effect associations between BW,BL and As levels,both in boys and girls.However,significant positive dose effects were found with As levels and HC in boys (r=0.25,P=0.004). 【Conclusion】 The level of arsenic during fetal period is low in Shanghai,and it found that there is no effect on BW and BL in this range of arsenic exposure.

Key words: umbilical cord blood, arsenic, fetus, physical growth

摘要： 【目的】 调查上海市胎儿期砷暴露水平,分析新生儿体格生长指标与新生儿脐带血砷水平的关系。【方法】 调查2008年10月-2009年10月上海市10家医院足月分娩的产妇及新生儿,采集脐带血,测定脐带血砷浓度,分析脐带血砷与婴儿出生体重、头围、身长等体格生长指标的关系。【结果】 共收集了291名新生儿的脐带血,测定脐带血砷,最高值24.87 μg/L,最低值1.81 μg/L,几何均数(G±S)值为 (5.48±3.49) μg/L,中位数为5.42 μg/L。新生儿体重及身长与脐带血砷均无统计学意义的相关性,但脐带血砷在男婴中与头围呈正相关(r=0.25,P=0.004),但对女婴无影响。【结论】 上海市胎儿期砷暴露处于较低水平,该暴露水平对新生儿体重、身长未发现影响。

关键词: 脐血, 砷, 胎儿, 体格生长