Abstract: 【Objective】 To analyse the efficacy and possible mechanism of treating children bronchiolitis caused by respiratory syncytial virus (RSV) and post-infection inflammation of the air passage by budesonide atomizing inhalation. 【Methods】 120 children diagnosed with RSV bronchiolitis were randomly divided to atomizing group and common group.The number of pant days during the acute and recovery stage,hospitalization days and recurrence cases of these two groups were recorded and compared.The blood serum eosinophilic cationic proteins (ECP),IL-6,IL-8 and IL-10 during the acute and recovery stage were tested and compared between the two groups,and statistics analysis was carried out. 【Results】 There was statistics significance (P＜0.05) of the pant days,hospitalization days and recurrence cases compared between these two groups.The values of ECP,IL-6 and IL-8 in the acute stage were higher than those in the recovery stage(P＜0.05).The value of IL-10 in the acute stage was lower than in the recover stage (P＜0.05).The difference had statistics significance (P＜0.05) between the above said test results in the recovery stage of the atomizing group and common group. 【Conclusion】 Budesonide atomizing inhalation has significant effects in treating RSV bronchiolitis,and certain effects in preventing post-infection inflammation of air passage.

Key words: budesonide, respiratory syncytial virus, bronchiolitis, eosinophil cationic protein, Th2 cytokine

摘要： 【目的】 探讨吸入布地奈德治疗儿童呼吸道合胞病毒(respiratory syncytial virus,RSV)毛细支气管炎及感染后气道炎症的效果与可能发生机制。 【方法】 将确诊RSV毛细支气管炎120名患儿随机分成雾化组和常规组,记录比较急性期和恢复期喘息持续天数、住院天数及喘息再发例数;检测比较急性期与恢复期血清嗜酸粒细胞阳离子蛋白(eosinophil cationic protein,ECP)、IL-6、IL-8、IL-10结果,进行统计学分析。 【结果】 两组比较喘息持续天数、住院天数及喘息再发例数有统计学意义(P均＜0.05);ECP、IL-6、IL-8值在急性期高于恢复期(P<0.05),IL-10急性期低于恢复期(P<0.05),对比恢复期上述检测指标在雾化组和常规组变化,差异有统计学意义(P<0.05)。 【结论】 吸入布地奈德治疗RSV感染毛细支气管炎效果明显,防治RSV感染后气道炎症有一定疗效。

关键词: 布地奈德, 呼吸道合胞病毒, 毛细支气管炎, 嗜酸粒细胞阳离子蛋白, Th2细胞因子