Study on interleukin-6, tumor necrosis factor-α and nitic oxide in newborn with infection
- WEI Zhao-xia
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Abstract
【Objective】 To study the characters of some cytokines levels in newborn with sepsis and infection. 【Method】 Cytokines were measured by sanwich enzyme-linked immunosorbent assay and nitric acid deoxidize method. 【Results】 The plasma IL-6, IL-8 and TNF-α levels in newborn with sepsis were significantly higher than the health control group (P<0.01). The plasma IL-6 levels in common infection had no difference with the health control group(P>0.05). There were no difference of TNFα between infection with hypoxic-ischemic encephalopathy(HIE) and pure infection(P>0.05), the levels of IL-6 were lower(P<0.01) and NO were higher (P<0.01)in the firster. 【Conclusions】 The high levels of IL-6, TNF-α and NO in newborn plasma indicate infection. TNF-α might be sensitive markers of diagnosis and degree of neonatal infection. The levels of IL-6, NO care be affected by asphyxia of newborn.
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References
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[3] 冯小三,黄绍敏. 新生儿感染性疾病IL-26、IL-28和TNF-α的研究[J]. 中国优生与遗传杂志,2004,12 (1):93-95.
[4] Kurt AN,Aygun AD,Godekmerdan A,et al. Serum IL-1 beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis[J]. Mediators Inflamm,2007,2007:31397-31401.
[5] 华亚军,刘静,凌历,等. TNF-α和IL-2在新生儿全身炎症反应综合征中的临床价值[J].上海医药,2009,30(7):323-324.
[6] 吴素娟,邵肖梅,杨毅,等.新生儿细菌感染时血清TNF-α和IL-10水平变化[J].临床儿科杂志,2003,21(2):76-78.
[7] Schleifer KW,Mansfield JM.Suppressor macrophages in Arican trypanosomiasis T cell prdiferative responses by nitric oxide and prostaglandins[J].J Immunol,1993,151(10):492-503.
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[9] Santana C,Guindeo MC,Gonzalez G,et al.Cord blood levels of cy2 tokines as predictors of early neonatal sepsis[J].Acta Paediatr,2001,90 (10):1176-1181.
