Abstract: 【Objective】 To explore characters of bone metabolism in neonates. 【Methods】 The concentrations of serum osteocalcin (OC), beta-crossLaps (β-CTx), calcium, parathyroid hormone (PTH) and 25-hydroxycholecalciferol [25(OH)D₃] were measured in 30 appropriate for gestational age(AGA) term infants, 17 small for gestational age(SGA) term infants, 33 AGA preterm infants and 6 SGA preterm infants, and the data were statistically analyzed. 【Results】 The concentrations of serum OC in group of SGA term infant and AGA preterm infants were less than that in group of AGA term infant(P<0.05); The concentrations of serum β-CTx in group of AGA term infant was less than that in group of AGA preterm infant(P<0.05); The concentrations of serum calcium in group of SGA and AGA preterm infant was less than that in group of AGA term infant(P<0.05); The concentrations of serum PTH in group of AGA preterm infant was less than that in group of AGA and SGA term infant(P<0.05); The concentrations of serum 25(OH)D₃ had no statistical difference in group of AGA term infant 、SGA term infant、AGA preterm infant and SGA preterm infant(P>0.05). 【Conclusions】 The SGA term infant, AGA and SGA preterm infant easily occur metabolic bone diseases, the supervisal in metabolic bone diseases for them should be strengthened, and Vitamin D difficiency rickets in AGA term infant should be paid attention to supervise too.

Key words: osteocalcin, serum beta-crossLaps, serum calcium, parathyroid hormone, 25-hydroxycholecalciferol, neonates

摘要： 【目的】 探讨新生儿的骨代谢特点,为临床提供参考依据。 【方法】 选取30例足月适于胎龄儿(AGA)、17例足月小于胎龄儿(SGA)、33例早产AGA和6例早产SGA作为研究对象,检测血清骨钙素(OC)、β胶原分解片段(β-CTx)、血清钙(Ca²⁺)、甲状旁腺素(PTH)和25-羟胆骨化醇[25(OH)D₃]浓度,并采用方差分析和Q检验对检测结果进行统计学分析。 【结果】 足月SGA和早产AGA组血清OC浓度低于足月AGA组(P分别<0.01和<0.05);足月AGA组血清β-CTx浓度低于早产AGA组(P<0.05);早产AGA和SGA组血清Ca²⁺浓度低于足月AGA组(P均<0.05);早产AGA组血清PTH浓度低于足月AGA和SGA组(P分别<0.01和<0.05);四组血清25(OH)D₃浓度比较差异无统计学意义(P>0.05)。 【结论】 足月SGA、早产AGA和SGA与足月AGA相比容易发生代谢性骨病,应加强代谢性骨病的监测,同时还应注意足月AGA 维生素D缺乏性佝偻病的监测。

关键词: 骨钙素, 血清β胶原分解片段, 血清钙, 甲状旁腺素, 25-羟胆骨化醇, 新生儿