Abstract: 【Objective】 To investigate the blood pressure and the impact of related factors in 3-years old offspring with hypertension disorder complicating pregnancy(HDCP)mother. 【Methods】 Utilizing the group case-control study method, a follow-up study was carried out. 28 HDCP patients, 34 normotensive controls during pregnancy and all of their offspring were obtained. The information was collected by questionnaires. The anthropometric measurements, blood pressure, fasting blood glucose, lipids and serum uric acid were measured in HDCP and control. The height, weight and blood pressure were measured in the offspring. 【Results】 There was no statistical difference in blood pressure between off springs of the two groups(P＞0.05). The blood pressure of offspring was not associated with mother current blood pressure, presentational BMI, weight gain during pregnancy(P＞0.05). No effect of mother's current dyslipidemia, uric acid anomalies and cardiovascular risk factors aggregation on their offspring's blood pressure was found(P＞0.05). The offspring's systolic blood pressure was positively associated with their weight gain after birth(P＜0.05). There was no significant difference in weight gain between two group children(P＞0.05). 【Conclusions】 This study indicates that HDCP is not associated with systolic and diastolic blood pressures in the 3-year-old offspring. But weight gain after birth is associated with systolic blood pressure in the children.

Key words: hypertension disorder complicating pregnancy, offspring, blood pressure

摘要： 【目的】 探讨妊娠期高血压疾病(hypertension disorder complicating pregnancy, HDCP)患者子代3岁时的血压及相关因素对其影响。 【方法】 采用成组病例对照研究方法,获取28例HDCP患者及其子代和34例正常妊娠妇女及其子代,通过问卷调查收集他们的基本情况。母亲通过体格检查测定身高、体重、腰围、臀围、血压,并计算BMI等。实验室测定空腹血糖、血脂及血清尿酸。对子代测量身高、体重、血压等。 【结果】 两组子代血压差异无统计学意义(P＞0.05);母亲血压、孕前BMI、孕期增重与子代3岁时的血压无相关性(P＞0.05);母亲目前的血脂异常、尿酸异常以及心血管危险因素聚集等亦未见对子代血压产生影响(P＞0.05)。儿童体重增加与儿童收缩压正相关(P＜0.05),HDCP组与正常对照组子代体重增重未见差异(P＞0.05)。 【结论】 本研究显示妊娠期高血压疾病与其子代3岁时的血压无相关性,但发现其收缩压与生后体重增加之间存在正相关。

关键词: 妊娠期高血压疾病, 子代, 血压