Controlled study of polymorphism of catechol-O-methyltransferase gene on children with attention deficit hyperactivity disorder

XIONG Zhong-gui; HU Xin-wen; XU Hai-qing; WANG Feng; SHI Shu-hua

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Chinese Journal of Child Health Care ›› 2011, Vol. 19 ›› Issue (3) : 222-223.

Controlled study of polymorphism of catechol-O-methyltransferase gene on children with attention deficit hyperactivity disorder

XIONG Zhong-gui¹, HU Xin-wen¹, XU Hai-qing¹, WANG Feng¹, SHI Shu-hua²

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Abstract

【Objective】 To analyze the correlation between attention deficit hyperactivity disorder(ADHD) in children and Val158Met polymorphism of catechol-O-methyltransferase(COMT) gene caused by the missense mutation of G158A. 【Methods】 The Val158Met polymorphism of COMT gene was tested in 110 children with ADHD and 90 non-ADHD by using quantitative PCR technique. 【Results】 The frequencies of A allele were 22.73% and 23.33% in case and controlled group respectively, which showed no significant difference between the two groups(χ²=0.021,P>0.05). There was also no significant difference in the distribution of all genotypes of COMT gene between the two groups(χ²=3.668,P>0.05). 【Conclusions】 It is suggested that there is no association between ADHD in children and Val158Met polymorphism of COMT gene in this study.

Key words

attention deficit hyperactivity disorder / catechol-O-methyl transferase / genetic polymorphism

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XIONG Zhong-gui, HU Xin-wen, XU Hai-qing, WANG Feng, SHI Shu-hua. Controlled study of polymorphism of catechol-O-methyltransferase gene on children with attention deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2011, 19(3): 222-223

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