【Objective】 To analyze the current status of hand-foot-mouth disease (HFMD) in Wenzhou City, so as to provide a scientific basis for the government to make the strategy of preventing and controlling HFMD. 【Methods】 The data of HFMD from the National Disease Surveillance Information Reporting System were conducted for statistical analysis and epidemiological description. 【Results】 A total of 20 443 cases of local HFMD were reported in Wenzhou in 2009 with an incidence of 236.87/10⁵. The cases mainly occurred from September to November,which accounted for 51.62%. The ratio of male and female was 1.71∶1. Most of the HFMD patients were the children aged 0 to 5 years old, accounting for 95.84%. The cases who were 0 to 3 years old accounted for 83.07%. There were most cases in the group of scattered inhabiting children, which accounted for 76.38%. Fifty-five of 94 severe cases were laboratory confirmed, with the result of 37 cases tested EV71 positive. 【Conclusions】 The epidemiological characteristics should be considered in the surveillance and prevention of HFMD, especially the local epidemic peaks and the risk populations.