Abstract: 【Objective】 To explore the changement of serum tumor necrosis factor-alpha-alpha (TNF-α), interleukin-4(IL-4),interleukin-6(IL-6) with allergic purpura and allergic purpura nephritis during the course of the disease. 【Methods】 The serum levels of TNF-α,IL-4,IL-6 were measured with ELISA. 【Results】 At the acute stage, the lever of serum TNF-α, IL-6, IL-4 in HSP group were significantly higher than those in normal control group (P<0.01), in convalescent stage, the lever of serum TNF-α, IL-4, IL -6 were obviously decreased, and the lever of serum TNF-α,IL-4 ,IL-6 were higher in HSPN than in HSP. 【Conclusion】 Cytokine disorder existed in the children with HSP,the TNF-α, IL-4, IL-6 may play important roles in patho-genesis of HSP and HSPN.

Key words: henoch-schonlein purpura, TNF-α, IL-4, IL-6

摘要： 【目的】 探讨肿瘤坏死因子-α( TNF-α)、白细胞介素-4(IL-4)和白细胞介素-6(IL-6)在过敏性紫癜和过敏性紫癜肾炎发病过程中的变化。 【方法】 采用双抗体夹心ELISA法检测过敏性紫癜患儿血清TNF-α、IL-4和IL-6的浓度。 【结果】 HSP急性期血清TNF-α、IL-4和IL-6水平明显高于对照组(P<0.01);在恢复期,TNF-α、IL-4和IL-6则明显下降;并且在过敏性紫癜肾中TNF-α、IL-4、IL-6浓度较HSP略高(P<0.05)。 【结论】 过敏性紫癜患儿存在细胞因子紊乱,TNF-α、IL-4和IL-6在过敏性紫癜和过敏性紫癜肾炎发病中发挥了一定的作用。

关键词: 过敏性紫癜, TNF-α, IL-4, IL-6