Protective effect and mechanism of insulin-like growth factor 1 in preterm infants with white matter damage

doi:10.11852/zgetbjzz2022-1285

Abstract

Abstract: White matter damage (WMD) in preterm infants, as a demyelinating disease, has a variety of pathogenesis and forms of damage. Due to the lack of specific treatment, it is the main cause of long-term sequelae such asperceptual disability, cognitive impairment and emotional disorder in preterm infants. Ithas been reported that the fine-tuning of insulin-like growth factor-1(IGF-1) levels by upstream events of WMD may lead to myelination disorders, and targeted supplementation of recombinant human insulin-like growth factor-1(rh-IGF-1) can not only promote the development of oligodendrocytes(OLs) and myelin maturation in WMD, but also reverse the neurobehavioral abnormalities caused by WMD. In view of this, this article reviews the progress of IGF-1 in WMD.

Key words: preterm infants, insulin-like growth factor-1, white matter damage, oligodendrocytes, myelination

摘要： 脑白质损伤(WMD)作为一种脱髓鞘疾病,发病机制及损伤形式多样、治疗手段有限,是目前早产儿发生情感障碍、认知障碍、感知觉障碍等神经系统后遗症的重要原因。据报道,WMD的上游事件对髓鞘的损害可能与胰岛素样生长因子1(IGF-1)水平的微调相关。IGF-1作为神经营养因子不仅可以促进WMD时少突胶质细胞(OLs)的发育、髓鞘的成熟,甚至可以逆转WMD带来的神经行为异常。鉴于此,现就IGF-1对WMD的保护作用及其机制等研究进展进行综述。

关键词: 早产儿, 胰岛素样生长因-1, 脑白质损伤, 少突胶质细胞, 髓鞘

CLC Number:

R722.6

MA Hongfang, XUE Jiang, LIANG Shuang. Protective effect and mechanism of insulin-like growth factor 1 in preterm infants with white matter damage[J]. Chinese Journal of Child Health Care, 2023, 31(11): 1219-1224.

马红芳, 薛江, 梁爽. 胰岛素样生长因子-1对早产儿脑白质损伤的保护作用及其机制[J]. 中国儿童保健杂志, 2023, 31(11): 1219-1224.

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