Abstract: Objective To analyze the relationship between mental health of parents and therapy compliance for children with phenylketonuria(PKU) in Xi'an. Methods During January 2013 to August 2015,50 parents of PKU children were assessed with Symptom Checklist 90.They were diagnosed and treated in our hospital.Under the investigation on mental health of parents with PKU children,the factor scores were divided into group Ⅰ and Ⅱ.The normal people whose children were checked in child healthcare department were taken as control. Results The mental health levels of parents with PKU children were significantly lower than those of control group(P＜0.01).The mental health levels of parents with PKU children in groupⅡwere significantly lower than those of groupⅠ (P＜0.01).groupⅡ showed a good treatment compliance(χ²=9.717,P＜0.01).Logistic regession analysis suggested that family income was risk factor of mental health of parents.Family income and educational levels were important factors of children's treatment compliance. Conclusion It is very necessary that throughing health education to psychological counseling for parents of PKU children,in order to alleviate the parents psychological pressure and improve the compliance for children.

Key words: phenylketonuria, treatment compliance, psychological pressure, influencing factors

摘要： 目的 探讨西安市苯丙酮尿症(PKU)患儿家长的心理状况与患儿治疗依从性相关分析。方法 2013年1月-2015年8月,在本院确诊、治疗随诊的50名PKU患儿及其家长为研究对象,让家长现场填写自编情况调查表和症状自评量表(SCL-90)进行调查,按心理症状因子得分分成1组和2组,对照组是同期来本院儿保门诊儿童家长64名。结果 PKU患儿家长SCL-90各因子得分与对照组比较差异均有统计学意义(P＜0.01)。2组PKU患儿家长在SCL-90量表中各因子得分普遍高于1组家长得分,差异有统计学意义(P＜0.01);1组患儿治疗依从性显著好于2组,两组差异有统计学意义(χ²=9.717,P＜0.01)。Logistic回归分析显示家庭收入是影响患儿家长心理的危险因素;家庭收入和家长文化程度是PKU患儿治疗依从性的影响因素。结论 多渠道开展健康教育,对患儿家长心理进行疏导,对改善患儿家长心理压力,提高患儿治疗依从性具有重要意义。

关键词: 苯丙酮尿症, 治疗依从性, 心理状况, 影响因素