Objective To investigate the relationship between the locus rs1800683 G>A polymorphisms of lymphotoxin-alpha (LTA) gene with Kawasaki disease (KD). Method The Sanger gene sequencing method was employed to detect the genotype of locus rs1800683 G>A polymorphisms of LTA gene in 100 patients with KD and 92 healthy controls. Results For locus rs1800683 G>A polymorphism in LTA gene,there was no significant difference between the KD and healthy controls in genotyping frequencies of AG,AA and GG respectively (χ2=3.78,P>0.05),and there was no significant difference in the allele frequencies of A and G between the two groups (χ2=2.84,P>0.05).There were no significant differences between the KD complicated with coronary artery injury (CAL) group and non coronary artery lesion (NCAL) group in genotyping frequencies of AG,AA and GG respectively (χ2=3.76,P>0.05) and in the allele frequencies of A and G between the two groups (χ2=0.43,P>0.05). Conclusion The locus rs1800683 G>A polymorphisms of LTA gene maybe not associated with the risks of KD and the coronary artery injury.
Key words
lymphotoxin-alpha gene /
polymorphism /
Kawasaki disease
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