Correlative factors influencing efficacy of recombinant human growth hormone treatment in short stature children.

doi:10.11852/zgetbjzz2015-23-02-11

journal1 ›› 2015, Vol. 23 ›› Issue (2): 147-149.DOI: 10.11852/zgetbjzz2015-23-02-11

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Correlative factors influencing efficacy of recombinant human growth hormone treatment in short stature children.

GUO Chun-yan¹,HE Bo¹,HU Yan-jia¹,YIN Chun-yan²,XIAO Yan-feng².

1 Children's Hospital of Yulin,Yulin,Shaanxi 719000,China;
2 Department of Pediatrics,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710004,China

Received:2014-05-20 Online:2015-02-10 Published:2015-02-10
Contact: HE Bo,E-mail:Hebo6266@163.com

重组人生长激素对身材矮小儿童增高疗效的相关影响因素分析

郭春艳¹，贺波¹，呼延佳¹，尹春燕²，肖延风²

1 榆林市儿童医院，陕西榆林 719000；
2 西安交通大学第二附属医院儿科，陕西西安 710004

通讯作者: 贺波,E-mailhebo6266@163.com
作者简介:郭春艳(1978-)，女，陕西人，主治医师，学士学位，主要研究方向为儿童生长发育。

Abstract

摘要： 目的探讨重组人生长激素对矮小症患儿身高增长的影响因素，为进一步制定重组人生长激素(recombinant human growth hormone，rhGH)治疗方案提供依据。方法以rhGH治疗时间超过6个月~2年的103例矮小症患儿为对象，将治疗后身高增长(Y)设为因变量，以年龄，身高，体重，靶身高，身高标准差分值，骨龄，父亲身高，母亲身高，实际年龄(CA)-骨龄(bone age，BA)，BA/CA，生长激素峰值，治疗时间和诊断作为自变量，采用多元逐步回归分析，评价影响rhGH治疗对身高增长疗效的因素。结果多元线性回归分析结果显示，rhGH 治疗后身高增长与治疗前患儿身高呈负相关，与治疗时间，遗传靶身高，父亲身高，BA与CA的差值与疗效呈正相关。结论骨龄落后的程度、开始治疗时身高、靶身高可作为预测rhGH增高疗效的指标之一。

关键词: 矮小儿童, 重组人生长激素, 疗效, 影响因素

CLC Number:

R153.2

GUO Chun-yan,HE Bo,HU Yan-jia,YIN Chun-yan,XIAO Yan-feng.. Correlative factors influencing efficacy of recombinant human growth hormone treatment in short stature children.[J]. journal1, 2015, 23(2): 147-149.

郭春艳，贺波，呼延佳，尹春燕，肖延风. 重组人生长激素对身材矮小儿童增高疗效的相关影响因素分析[J]. 中国儿童保健杂志, 2015, 23(2): 147-149.

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Correlative factors influencing efficacy of recombinant human growth hormone treatment in short stature children.

重组人生长激素对身材矮小儿童增高疗效的相关影响因素分析

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