Objective To understand the effects of early comprehensive intervention on early developmental quotient of premature infants and provide clinical basis for early comprehensive intervention on premature infants. Methods Participants falled into two groups.Treatment group included parents participating actively in early intervention,and control group included parents who didn't participate for various reasons.By regular follow-up and early intervention,《0~6 year-old Children's Neuropsychological Development Scale》 compiled by the capital institute of pediatrics was used to test development quotient of 6 months premature infants. Results Abnormal proportion of 20 items of neuromotor assessment ≥3 was corrected,intervention group was 8.6%,control group was 30%,and there was a statistical difference between the two groups (χ²=5.35,P<0.05);Project of one or more abnormal proportion was 20% in intervention group and 50% in control group,the difference between the two groups was statistically significant (χ²=7.29,P<0.05);When correcting 6 months,assessment,results showed that except for gross movement,intervention group infants' DQ values were higher than no intervention group in the rest four zones,with a statistical significance of the difference (fine movement t=4.81,adaptive capacity t=3.42,language t=5.33,social behavior t=3.45,all P<0.01). Conclusion Effective early comprehensive intervention can improve neuro motor development of premature,and it has positive effect on premature infants' early developmental quotient.