Objective To analyze the related factors of extrauterine growth restriction (EUGR) in premature infants dis-charged from hospital, and provide clinical basis for preventing occurrence of EUGR. Methods The premature infants born from February 2012 to February 2013 in NICU were selected.Growth restriction was defined asmeasured growth values≤10^th percentile of the values of growth expectation based on estimated postmenstrual age. Results The incidence of EUGR in weight less than equal to 1 500 g group was 66.2%, the incidence of EUGR in weight greater than 1 500 g group was 37.8%, the difference was significant (P<0.05).The incidence of EUGR in less than 34 weeks gestational age group was 71.3%, the incidence of EUGR in the greater than or equal to 34 weeks gestational age group was 44.8%, the difference was significant (P<0.01).It was showed that risk factor related to EUGR were intrauterine growth retardation ( IUGR )and infection, the lasting time of weight decrease after birth. Conclusions EUGR is closely related to gestational age and birth weight.The cause of EUGR are multi-facorial, so complications should be prevented and treated actively.Early attention to nutrition, shorten the lasting time of weight decrease after birth, is the key to avoiding EUGR.