过敏性紫癜血清TNF-α、IL-4和IL-6的变化及临床意义

中国儿童保健杂志 ›› 2011, Vol. 19 ›› Issue (1): 77-80.

过敏性紫癜血清TNF-α、IL-4和IL-6的变化及临床意义

刘文东,于凌翔,薛爱红,李红

青岛市市立医院,山东青岛 266071

发布日期:2011-01-06 出版日期:2011-01-06
作者简介:刘文东(1977-),男,山东人,主治医师,硕士学位,主要研究方向是小儿呼吸系统及感染性疾病

Changes and clinical significance of serum TNF-α, IL-4 and IL-6 in the children with henoch-schonlein purpura

LIU Wen-dong, YU Ling-xiang, XUE Ai-hong, LI Hong

Qingdao Municipal Hospital, Qingdao, Shandong 266071, China

Online:2011-01-06 Published:2011-01-06

摘要/Abstract

摘要： 【目的】探讨肿瘤坏死因子-α( TNF-α)、白细胞介素-4(IL-4)和白细胞介素-6(IL-6)在过敏性紫癜和过敏性紫癜肾炎发病过程中的变化。【方法】采用双抗体夹心ELISA法检测过敏性紫癜患儿血清TNF-α、IL-4和IL-6的浓度。【结果】 HSP急性期血清TNF-α、IL-4和IL-6水平明显高于对照组(P<0.01);在恢复期,TNF-α、IL-4和IL-6则明显下降;并且在过敏性紫癜肾中TNF-α、IL-4、IL-6浓度较HSP略高(P<0.05)。【结论】过敏性紫癜患儿存在细胞因子紊乱,TNF-α、IL-4和IL-6在过敏性紫癜和过敏性紫癜肾炎发病中发挥了一定的作用。

关键词: 过敏性紫癜, TNF-α, IL-4, IL-6

Abstract: 【Objective】 To explore the changement of serum tumor necrosis factor-alpha-alpha (TNF-α), interleukin-4(IL-4),interleukin-6(IL-6) with allergic purpura and allergic purpura nephritis during the course of the disease. 【Methods】 The serum levels of TNF-α,IL-4,IL-6 were measured with ELISA. 【Results】 At the acute stage, the lever of serum TNF-α, IL-6, IL-4 in HSP group were significantly higher than those in normal control group (P<0.01), in convalescent stage, the lever of serum TNF-α, IL-4, IL -6 were obviously decreased, and the lever of serum TNF-α,IL-4 ,IL-6 were higher in HSPN than in HSP. 【Conclusion】 Cytokine disorder existed in the children with HSP,the TNF-α, IL-4, IL-6 may play important roles in patho-genesis of HSP and HSPN.

Key words: henoch-schonlein purpura, TNF-α, IL-4, IL-6

中图分类号:

R725.5

刘文东,于凌翔,薛爱红,李红. 过敏性紫癜血清TNF-α、IL-4和IL-6的变化及临床意义[J]. 中国儿童保健杂志, 2011, 19(1): 77-80.

LIU Wen-dong, YU Ling-xiang, XUE Ai-hong, LI Hong. Changes and clinical significance of serum TNF-α, IL-4 and IL-6 in the children with henoch-schonlein purpura[J]. journal1, 2011, 19(1): 77-80.

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