粪菌移植治疗儿童孤独症谱系障碍的研究进展

doi:10.11852/zgetbjzz2023-1151

摘要/Abstract

摘要： 孤独症谱系障碍(ASD)是一类以社会交流障碍及刻板行为为特征的神经发育障碍性疾病,其发病机制复杂,由遗传因素及环境因素共同作用。近年来,研究发现肠道菌群失调或许是ASD发生的重要环境因素,寻找ASD患者群体较正常发育群体肠道菌群及代谢组学的显著差异特征对探索ASD发病机制和临床诊疗或将有重要意义。ASD的治疗目前以行为干预为主,但效果欠佳。近年来,以纠正肠道菌群紊乱、恢复肠道稳态为理论基础的治疗应运而生,其中以粪菌移植最具代表性。本文旨在总结针对肠道菌群紊乱及代谢组学改变在ASD发生发展中的研究现状及粪菌移植在ASD群体中的应用进展,为未来ASD的探索提供新思路。

关键词: 孤独症谱系障碍, 粪菌移植, 脑肠轴, 代谢紊乱

Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions and communications together with repetitive and restrictive behaviors.The pathogenesis of ASD is complex and heterogeneous.Genetic and environmental factors are associated with the development of ASD.Current researches proposed gut microbiota dysbiosis may be an important trigger in the development of ASD,so the exploration of significant differences in the gut microbiota and metabolomics between individuals with ASD and typically developed individuals may have great significance for understanding the pathogenesis of ASD and clinical diagnosis and treatment.Behavioral interventions are the mainstay of ASD treatment,but their efficacy is limited.Recently,treatments based on the theory of correcting gut microbiota disturbance and restoring intestinal homeostasis have emerged,among which fecal bacteria transplantation is the most representative.In this review,the progress of gut microbiota dysbiosis and metabolomic changes in the occurrence and development of ASD is summarized,and the current research status of fecal microbiota transplantation intervention in ASD population is elucidated,so as to provide new insights for future fecal microbiota transplantation research.

Key words: autism spectrum disorder, fecal microbiota transplantation, brain-gut-axis, metabolic disturbance

中图分类号:

R749.94

王丽红, 于连虎, 曹爱华. 粪菌移植治疗儿童孤独症谱系障碍的研究进展[J]. 中国儿童保健杂志, 2025, 33(1): 83-87.

WANG Lihong, YU Lianhu, CAO Aihua. Advances in the treatment of autism spectrum disorder by fecal microbiota transplantation[J]. Chinese Journal of Child Health Care, 2025, 33(1): 83-87.

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