新生儿缺氧性肺动脉高压发病机制的研究进展

中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (10): 1058-1061.

新生儿缺氧性肺动脉高压发病机制的研究进展

徐焕丽，陈敬国

中山市人民医院，广东中山 528400

收稿日期:2014-02-09 发布日期:2014-10-10 出版日期:2014-10-10
通讯作者: 陈敬国,E-mail:chenjingguo@126.com
作者简介:徐焕丽(1985-)，女，河南人，硕士学位，研究方向为新生儿疾病。

Received:2014-02-09 Online:2014-10-10 Published:2014-10-10

摘要/Abstract

摘要： 新生儿缺氧性肺动脉高压(hypoxia-induced pulmonary hypertension of the newborn，HPH)的发生涉及很多方面，肺血管收缩反应增强和肺血管结构重建是肺动脉高压形成的血管变化特征。而目前HPH的发病机制仍不清楚，但近年来研究表明缺氧诱导因子-1α(hypoxia inducible factor，HIF-1α)及其诱导因子内皮素-1(endothelia -1，ET-1)、促红细胞生成素(erythropoietin，EPO)及血管内皮生长因子(vascular Endothelia factor，VEGF)在肺动脉高压的发生、发展中发挥重要作用。本文将对HIF-1α、ET-1、EPO、VEGF在新生儿低氧性肺动脉高压发病中的重要作用及其进展进行简要概述。

关键词: 低氧性肺动脉高压, 缺氧诱导因子-1α, 内皮素-1、促红细胞生成素, 血管内皮生长因子

中图分类号:

R722.1

徐焕丽，陈敬国. 新生儿缺氧性肺动脉高压发病机制的研究进展[J]. 中国儿童保健杂志, 2014, 22(10): 1058-1061.

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