下丘脑-垂体-性腺轴功能评估方法在诊断儿童性早熟中的进展

中国儿童保健杂志 ›› 2013, Vol. 21 ›› Issue (8): 823-825.

下丘脑-垂体-性腺轴功能评估方法在诊断儿童性早熟中的进展

李雪宁综述, 赵亚茹审校

中国医科大学附属盛京医院发育儿科,辽宁沈阳 110004

收稿日期:2013-04-19 发布日期:2013-08-06 出版日期:2013-08-06
通讯作者: 赵亚茹,E-mail:zhaoyaru@163.com
作者简介:李雪宁(1988-),男,河南人,在读硕士,主要研究方向为儿童生长发育。

Received:2013-04-19 Online:2013-08-06 Published:2013-08-06

摘要/Abstract

摘要： 下丘脑-垂体-性腺轴(hypothalamic-pituitary-gonadal axis,HPGA)对人体生殖系统的发育、功能状态的维持具有重要的作用,判断 HPGA 功能状态是儿童性发育异常性疾病诊疗路径中的关键步骤之一。目前大家公认的评估儿童 HPGA 功能状态的实验室金标准是经典的促性腺激素释放激素(gonadotropin releasing hormone,GnRH)激发试验,但该试验存在采血次数多、费用较高、操作复杂、患儿及家长依从性差等缺点,使其在临床应用方面受到一定限制。随着促性腺激素(gonadotrophin,Gn)检测技术的发展,检测灵敏度得到了极大提高,为临床及科研工作者寻求更简单、更方便的方法来评估HPGA功能状态创造了条件。本文主要阐述目前在简化GnRH 激发试验以及探索可替代经典的GnRH 激发试验来评估HPGA功能状态的研究现状。

中图分类号:

R725.8

李雪宁综述, 赵亚茹审校. 下丘脑-垂体-性腺轴功能评估方法在诊断儿童性早熟中的进展[J]. 中国儿童保健杂志, 2013, 21(8): 823-825.

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