关键词: 抽动秽语综合征, 抗链球菌溶血素O, IL-6, IL-8, T淋巴细胞亚群

Abstract: Objective To observe the changes of blood T-cell subpopulations,ASO,IL-6 and IL-8 in children with Tourette's syndrome (TS) and explore the pathogenesis. Methods T-cell subpopulations and concentration of IL-6,IL-8,ASO were measured in 32 children with TS and 30 normal children using SAP and ELISA.Yale global tic severity scale(YGTSS) was used to evaluate the severity of tic disorder in children with GTS. Results The numbers of CD⁺₃,CD⁺₄ and CD⁺₈ cells were no significant differences between 32 children with Tourette’s syndrome and 30 normal children(P>0.05),and the levels of IL-6[(68.12±28.13)ng/L] and ASO[(351.4±27.6)kU/L]in serum of children with Tourette's syndrome were significantly higher than those in normal children[(240.8±20.9)kU/L,(48.48±26.21)ng/L](P<0.05).No statistical significance of IL-8 was found in two groups. Conclusion There may be disfunction in humoral immunity in Tourette's syndrome.The pathogenesis of Tourette's syndrome may should be improved in future.

Key words: Tourette&apos, s syndrome, ASO, IL-6, IL-8, T-cell subpopulations