关键词: 被动吸烟, 新生儿低出生体重, 病例对照研究

Abstract: Objective To detect the relationship between passive tobacco smoking exposure during pregnancy and low birth weight (LBW) neonates. Method A 1∶2 case control study was carried out among 1 080 women included 360 cases and 720 controls,aged 20 to 30 years who gave births in maternal care hospital of Ezhou from Jan 1st 2008 to Dec 31st 2011.Mothers giving birth to LBW neonate (<2.5 kg) were cases and those whose neonates weighed ≥2.5 kg at birth were controls.Information on passive tobacco smoking exposure and other potential risk factors of LBW within 24 hours of delivery were collected from hospital records and face to face investigation. Results The passive tobacco smoking exposure rate was higher in cases group (47.5%) than controls group (28.3%,P<0.001),and the OR was 1.30 times higher accordingly.The adjusted OR were 1.54 times(OR=2.54,95% CI:1.81~3.57) and 3.29 times (OR=4.29,95% CI:2.62~7.04)higher in cases who had accumulative exposed in passive tobacco smoking 1~3 days/week and >3 days/week than controls.And the AFe were 60.6% and 76.7%,respectively.Pregnant women who had taken antenatal examination more than 7 times might associate with 53% (OR=0.47,95% CI:0.30~0.73) decrease risk of low birth weight neonates. Conclusion There is a closely association and a significant dose-response relationship between passive tobacco smoking and low birth weight of neonates.

Key words: passive tobacco smoking, low birth weight neonate, case-control study