热性惊厥患儿血清脑源性神经营养因子的变化及与智能发育的关联性研究
- 周菊花,方素珍,周细中,杜江,赵倩,李宏
作者信息
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Relationship between intellectual development and changes of serum brain-derived neurotrophic factor in children with febrile seizures.
- ZHOU Ju-hua,FANG Su-zhen,ZHOU Xi-zhong,DU Jiang,ZHAO Qian,LI Hong.
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文章历史
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摘要
目的 探讨血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)在热性惊厥(febrile seizuresi,FS)患儿发生发展过程中的病理生理学作用,并分析其与发作后脑电图(electroencephalogram,EEG)和智能发育的关系。方法 采用酶联免疫吸附法测定FS患儿(n=73)、急性上呼吸道感染无FS患儿(n=51)、健康儿童(n=43)血清BDNF水平,EEG检测FS患儿脑电活动,发育量表评估患儿恢复后智能发育情况。结果 FS组血清BDNF浓度均显著高于上感组和正常组(P<0.01);EEG异常组血清BDNF浓度均高于EEG正常组(P＜0.01或＜0.05),且EEG发作性异常有高度统计学意义。小儿发育商与血清BDNF无明显相关(P=0.144)。 结论 FS患儿血清BDNF浓度明显增加,可能参与了FS的发生和发展过程;BDNF有望作为评估惊厥后脑损伤敏感指标;小儿智能发育指数与血清BDNF无明显相关性。
Abstract
Objective To investigate the pathophysiological effects of serum brain-derived neurotrophic factor (BDNF) level and analyse the relationship with the electroencephalogram (EEG) and mental development in the process of febrile seizures (FS). Methods All cases were divided into three groups.Experimental group was the children with FS(n=73);Control group was the children with acute upper respiratory infection(n=51) and healthy children(n=43).The serum BDNF levels of all groups were detected by ELISA;The brain activity was examined by EEG;The mental development index(DQ) was assessed by development scale. Results The serum BDNF levels in experimental group were greatly higher than those of the control groups(P<0.01).The serum BDNF levels were significantly increased in children with abnormal EEG(P＜0.01 or ＜0.05),especially the children with seizure abnormal EEG.There was no significant correlation between DQ and the serum BDNF(P=0.144). Conclusions The serum BDNF levels in experimental group is significantly increased and might be involved in the development process of FS.BDNF is expected to be a sensitive index for evaluating the degrees of brain damage.There was no significant correlation between serum BDNF and DQ.
关键词
Key words
febrile seizures / brain-derived neurotrophic factor / EEG / development of mental
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参考文献
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[2] Louhivuori V,Arvio M,Soronen P,et al.The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome[J].Epilepsy Res,2009,85(1):114-117.
[3] Heinrich C,Lahteinen S,Suzuki F,et al.Increase in BDNF mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy[J].Neurobiology of Disease,2011,42(1):35-47.
[4] Gerald M,Fenichel MD.Clinical pediatric neurology[M].America:Demos Medical Publishing,2009:517-520.
[5] 周戬平,王帆,李瑞林,等.热性惊厥对大鼠行为运动及空间学习记忆的影响[J].中华儿科杂志,2004,42(1):49-53.
[6] Shin EJ,Jeong JH,Chung YH,et al.Role of oxidative stress in epileptic seizures[J].Neurochem Int,2011,59(2):122-137.
[7] Heinrich C,Lahteinen S,Suzuki F,et al.Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy[J].Neurobiol Dis,2011,42(1):35-47.
[8] Flávia RC,Joseph DW,Mayurika D,et al.BDNF-TrkB pathway mediates NMDA receptor NR2B subunit phosphorylation in the supraoptic nuclei following progressive dehydration[J].J Neuroendocrinol,2011,23(10):894-905.
[9] Arancibia S,Silhol M,Mouliere F,et al.Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats[J].Neurobiol Dis,2008,31(3):316-326.
[10] Phu VT,Stephanie JB,Fretham BS,et al.Long-term reduction of hippocampal BDNF activity following fetal-neonatal iron deficiency in adult rats[J].Pediatr Res,2009,65(5):493-498.
[11] Cunha C,Brambilla R,Thomas KL.A simple role for BDNF in learning and memory?[J].Front Mol Neurosci,2010,3:1-10.
[12] Soliman F,Glatt CE,Bath KG,et al.A genetic variant BDNF polymorphism alters extinction learning in both mouse and human[J].Science,2010,327(5967):863-866.
[13] Reiss JI,Dishman RK,Boyd HE,et al.Chronic activity wheel running reduces the severity of kainic acid-induced seizures in the rat:possible role of galanin[J].Brain Res,2009,1266:54-63.
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