关键词: 热性惊厥, 脑源性神经营养因子, 脑电图, 智能发育

Abstract: Objective To investigate the pathophysiological effects of serum brain-derived neurotrophic factor (BDNF) level and analyse the relationship with the electroencephalogram (EEG) and mental development in the process of febrile seizures (FS). Methods All cases were divided into three groups.Experimental group was the children with FS(n=73);Control group was the children with acute upper respiratory infection(n=51) and healthy children(n=43).The serum BDNF levels of all groups were detected by ELISA;The brain activity was examined by EEG;The mental development index(DQ) was assessed by development scale. Results The serum BDNF levels in experimental group were greatly higher than those of the control groups(P<0.01).The serum BDNF levels were significantly increased in children with abnormal EEG(P＜0.01 or ＜0.05),especially the children with seizure abnormal EEG.There was no significant correlation between DQ and the serum BDNF(P=0.144). Conclusions The serum BDNF levels in experimental group is significantly increased and might be involved in the development process of FS.BDNF is expected to be a sensitive index for evaluating the degrees of brain damage.There was no significant correlation between serum BDNF and DQ.

Key words: febrile seizures, brain-derived neurotrophic factor, EEG, development of mental