关键词: 先天性甲状腺功能减低症, 新生儿疾病筛查, 神经心理发育

Abstract: Objective To analyze the neural and psychological development of congenital hypothyroidism (CH) children from the newborn screening for CH,and provide evidences for estimating prognosis and exploring more perfect treatment. Method The DQ,motor,fine movement,adaption,language and social behavior of congenital hypothyroidism children were evaluated using neural and psychological development diagnosis scale for 0~6 years old children. Results Intelligence level of most CH children was in normal range,average scores of DQ were higher than 85 but in low-to-normal level in each age group.Neural and psychological development of CH children of different diagnosis age were not significantly different.The correlations between pretreatment FT₃ and fine movement,adaption,language,social behavior were significant (P<0.05),and the correlation coefficients were -0.282,-0.280,-0.276,-0.192,respectively.The correlation between pretreatment FT₄ and motor was significant (r=0.198,P<0.05). Conclusion Intelligence level of most CH children can achieve normal range.Both high FT₃ level and low FT₄ level can affect the neural and psychological developments of CH children.

Key words: congenital hypothyroidism, newborn screening, neural and psychological development