关键词: Ghrelin, 生长激素, 矮小儿童, 生长激素激发试验

Abstract: Objective To assess possible correlations between serum growth hormone(GH) and ghrelin values during the GH provocative tests in children with short stature. Methods Fifty seven prepubertal children with short stature were recruited in the study.Using the results of two GH-provocative tests(L-dopa and insulin),the children with short stature were divided into two groups:GHD and NGH.In both groups,serum GH and ghrelin levels were determined and possible correlations between GH and ghrelin values were assessed during the GH provocative tests. Results 1)Serum ghrelin levels had no statistical differences between GHD and NGH groups(P>0.05)during the GH provocative tests,either baseline ghrelin or peak ghrelin.2)No correlations were observed between ghrelin and GH levels either baseline or peak levels,both in GHD group and NGH group.3)Serum ghrelin levels were correlated with height,weight and BMI.But weight was the independent determinant on serum ghrelin levels. Conclusions No significantly correlations are observed between the ghrelin and GH levels in short stature children during the GH provocative tests.The results suggest that ghrelin do not play a main role during the control of GH secretion,although ghrelin possessing a strong growth hormone-releasing activity.

Key words: ghrelin, growth hormone, children with short stature, GH provocative tests