【目的】 了解广西地区新生儿疾病筛查促甲状腺素(thyrotropic-stimulating hormone,TSH)水平分布及筛查切值制定; 【方法】 对本区新生儿疾病筛查中心270 590例新生儿TSH筛查结果进行分析,使用百分位数法及ROC工作曲线计算TSH切值,并对不同切值情况下,确诊患者情况进行分析。 【结果】 新生儿疾病筛查TSH水平呈偏态分布,新生儿疾病筛查TSH水平P50为1.89 mU/L,P99为8.13 mU/L;结合ROC曲线结果得出本实验室TSH筛查切值为8.1 mU/L;根据其他方法提供的筛查切值,不同程度漏诊先天性甲状腺功能减退症患儿。 【结论】 不同的切值对筛查结果的影响较大,根据自身实验室实际情况制定适宜的切值是提高筛查质量的重要环节。
Abstract
【Objective】 In order to know the distribution of TSH and incidence of congintal hypothroid newborns in Guangxi provinces,and study the cutoff for newborn screen. 【Method】 The dates of newborn screen centre of Guangxi Zhuang Autoumous Region were analyzed,which was about 270 590 neonatals,and calculated the TSH cutoff by percent and ROC curve,then,analyzed the complexion of sufferers by different cutoff. 【Results】 The distribution of newborn screen was deflection,P50 was 1.89 mU/L,P99 was 8.13 mU/L,combined with ROC curve,the cutoff of our lab was 8.1 mU/L. 【Conclusion】 Different cutoff effect the consequences of newborn screen.To establish establish the suitable cutoff based on lab is important.
关键词
先天性甲状腺功能减退症 /
筛查 /
切值 /
促甲状腺素
Key words
congenital hypothyroidism /
newborn screen /
cutoff /
thyrotropic-stimulating hormone
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基金
广西壮族自治区卫生厅课题(22011085)
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