广西先天性甲状腺功能减退症新生儿筛查分析及切值的探讨

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (3): 248-250.

广西先天性甲状腺功能减退症新生儿筛查分析及切值的探讨

范歆,陈少科,林彩娟,李旺,俸诗瀚,罗静思,钱家乐,郭小芳,李正,何春雨

广西壮族自治区妇幼保健院,儿童医院,广西南宁 530003

收稿日期:2011-11-24 发布日期:2012-03-06 出版日期:2012-03-06
通讯作者: 陈少科,E-mail:chenshaoke123@163.com
作者简介:范歆(1981-),女,广西人,主治医师,硕士学位,主要研究方向为儿科内分泌疾病
基金资助:
广西壮族自治区卫生厅课题(22011085)

Analysis of Guangxi congenital hypothyroidism newborn screening and discussion the cutoff value

FAN Xin,CHEN Shao-ke,LIN Cai-juan,LI Wang,FENG Shi-han,LUO Jing-si,QIAN Jia-le,GUO Xiao-fang,LI Zheng,HE Chun-yu

Maternity and Child Care Health Hospital of Guangxi Province,Nanning,Guangxi 530003,China

Received:2011-11-24 Online:2012-03-06 Published:2012-03-06

摘要/Abstract

摘要： 【目的】了解广西地区新生儿疾病筛查促甲状腺素(thyrotropic-stimulating hormone,TSH)水平分布及筛查切值制定; 【方法】对本区新生儿疾病筛查中心270 590例新生儿TSH筛查结果进行分析,使用百分位数法及ROC工作曲线计算TSH切值,并对不同切值情况下,确诊患者情况进行分析。【结果】新生儿疾病筛查TSH水平呈偏态分布,新生儿疾病筛查TSH水平P₅₀为1.89 mU/L,P₉₉为8.13 mU/L;结合ROC曲线结果得出本实验室TSH筛查切值为8.1 mU/L;根据其他方法提供的筛查切值,不同程度漏诊先天性甲状腺功能减退症患儿。【结论】不同的切值对筛查结果的影响较大,根据自身实验室实际情况制定适宜的切值是提高筛查质量的重要环节。

关键词: 先天性甲状腺功能减退症, 筛查, 切值, 促甲状腺素

Abstract: 【Objective】 In order to know the distribution of TSH and incidence of congintal hypothroid newborns in Guangxi provinces,and study the cutoff for newborn screen. 【Method】 The dates of newborn screen centre of Guangxi Zhuang Autoumous Region were analyzed,which was about 270 590 neonatals,and calculated the TSH cutoff by percent and ROC curve,then,analyzed the complexion of sufferers by different cutoff. 【Results】 The distribution of newborn screen was deflection,P₅₀ was 1.89 mU/L,P₉₉ was 8.13 mU/L,combined with ROC curve,the cutoff of our lab was 8.1 mU/L. 【Conclusion】 Different cutoff effect the consequences of newborn screen.To establish establish the suitable cutoff based on lab is important.

Key words: congenital hypothyroidism, newborn screen, cutoff, thyrotropic-stimulating hormone

中图分类号:

R722.1

范歆,陈少科,林彩娟,李旺,俸诗瀚,罗静思,钱家乐,郭小芳,李正,何春雨. 广西先天性甲状腺功能减退症新生儿筛查分析及切值的探讨[J]. 中国儿童保健杂志, 2012, 20(3): 248-250.

FAN Xin,CHEN Shao-ke,LIN Cai-juan,LI Wang,FENG Shi-han,LUO Jing-si,QIAN Jia-le,GUO Xiao-fang,LI Zheng,HE Chun-yu. Analysis of Guangxi congenital hypothyroidism newborn screening and discussion the cutoff value[J]. journal1, 2012, 20(3): 248-250.

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