促红细胞生成素在新生儿的应用进展
- 吴英丽 综述, 卢宪梅,李文 审校
作者信息
+
文章历史
+
摘要
研究表明,促红细胞生成素(erythropoietin, EPO)具有防治贫血及神经保护的作用,并逐渐临床应用于新生儿。EPO750 U/(kg·W),分2次于生后早期给予早产儿,可有效防治早产儿贫血,但随访其远期效果不明显。高剂量EPO治疗新生儿脑损伤安全有效,并可促进患儿神经系统发育。
关键词
{{custom_sec.title}}
{{custom_sec.title}}
参考文献
[1] Ronald JM, Andran E. Erythropoietin (Epo) for infants with hypoxic-ischemic encephalopathy (HIE)[J]. Curr Opin Pediatr,2010,22(2):139-145.
[2] Miskowiak K, Inkster B, Selvaraj S, et al. Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration[J]. Neuropsychopharrmacology,2008,33:611-618.
[3] Khatami SF, Mamouri G, Torkaman M. Effects of early human recombinant erythropoietin therapy on the transfusion in healthy preterm infants[J]. Indian J Pediatr,2008,75(12):1227-1230.
[4] Soubasi V, Kremenopouios G, Diamanti E, et al. Follow-up of very low birth weight infants after erythropoietin treatment to prevent anemia of prematurity[J]. Pediatr,1995,127(2):291-297.
[5] Bierer R, Peceny MC, Hartenberqer CH, et al. Erythropoietin concentrations and neurodevelopmental outcome in preterm infants[J]. Pediatrics,2006,118(3):635-640.
[6] Brown MS, Eichorst D, Lala-Black B, et al. Higher cumulative doses of erythropoietin and developmental outcomes in preterm infants[J]. Pediatrics,2009,124(4):681-687.
[7] Ohlsson A, Aher SM. Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants[J]. Cochrane Database Syst Rev,2006,3:4865-4867.
[8] Kim SS, Lee KH, Sung DK, et al. Erythropoietin attenuates brain injury, subrentricular zone expansion, and sensorimotor deficits in hypoxic-ischemic neonatal rats[J]. J Korean Med Sci,2008,23(3):484-491.
[9] Kim MS, Seo YK, Park HJ, et al. The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats[J]. Korean J Pediatr,2010,53(10):898-908.
[10] Marcus Mazur MD, Robert HM, Shenandoah R. Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury[J]. J Neurosurg Pediatr,2010,6(3):201-221.
[11] 汪君,杨青.促红细胞生成素对大鼠脑损伤后神经保护作用的实验研究[J].中国临床神经外科杂志,2010,15(8):477-480.
[12] Kumral A, Ozer E, Yilmaz O, et al. Neuroprotective effect of erythropoietin on hypoxic-ischemic brain injury in neonatal rats[J]. Biol Neonate,2003,83(3):224-228.
[13] 刘海樱,徐英美,陈凤展,等.重组人促红细胞生成素对缺氧缺血性脑损伤学习记忆能力的保护[J].中国临床康复,2006,10(14):59-61.
[14] Fauchere JC, Dame C, Vonthein R, et al. An approach to using recombinant erythropoietin for neuroprotection in very preterm infants[J]. Pediatrics,2008,122(2):375-382.
[15] He JS, Huang ZL, Yang H, et al. Early use of recombinant human erythropoietin promotes neurobehavioral development in preterm infants[J]. Zhongguo Dang Dai Er Ke Za Zhi,2008,10:586-588.
[16] Neubauer AP,Voss W, Wachtendorf M, et al. Erythropoietin Improves Neurodevelopmental Outcome of Extremely Preterm Infants[J]. Ann Neurol,2010,67(5):657-666.
[17] 罗小燕,周翔,韩静.注射重组人促红细胞生成素对早产儿贫血及神经系统作用的防治分析[J].实用心脑肺血管病杂志,2010,18(8):1039-1040.
[18] Zhu C, Kang W, Xu F, et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy[J]. Pediatrics,2009,124:e218-226.
[19] 郭晓燕,朱长连,程秀永,等.亚低温与促红细胞生成素联合治疗新生儿缺氧缺血性脑损伤的效果[J].实用儿科临床杂志,2008,23,(2):111-113.
[20] 罗海龙,金玉玲.IGF-1和EPO对新生大鼠海马源性神经干细胞分化是实验研究[J].齐齐哈尔医学院学报,2008,29(5):530-532.
[2] Miskowiak K, Inkster B, Selvaraj S, et al. Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration[J]. Neuropsychopharrmacology,2008,33:611-618.
[3] Khatami SF, Mamouri G, Torkaman M. Effects of early human recombinant erythropoietin therapy on the transfusion in healthy preterm infants[J]. Indian J Pediatr,2008,75(12):1227-1230.
[4] Soubasi V, Kremenopouios G, Diamanti E, et al. Follow-up of very low birth weight infants after erythropoietin treatment to prevent anemia of prematurity[J]. Pediatr,1995,127(2):291-297.
[5] Bierer R, Peceny MC, Hartenberqer CH, et al. Erythropoietin concentrations and neurodevelopmental outcome in preterm infants[J]. Pediatrics,2006,118(3):635-640.
[6] Brown MS, Eichorst D, Lala-Black B, et al. Higher cumulative doses of erythropoietin and developmental outcomes in preterm infants[J]. Pediatrics,2009,124(4):681-687.
[7] Ohlsson A, Aher SM. Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants[J]. Cochrane Database Syst Rev,2006,3:4865-4867.
[8] Kim SS, Lee KH, Sung DK, et al. Erythropoietin attenuates brain injury, subrentricular zone expansion, and sensorimotor deficits in hypoxic-ischemic neonatal rats[J]. J Korean Med Sci,2008,23(3):484-491.
[9] Kim MS, Seo YK, Park HJ, et al. The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats[J]. Korean J Pediatr,2010,53(10):898-908.
[10] Marcus Mazur MD, Robert HM, Shenandoah R. Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury[J]. J Neurosurg Pediatr,2010,6(3):201-221.
[11] 汪君,杨青.促红细胞生成素对大鼠脑损伤后神经保护作用的实验研究[J].中国临床神经外科杂志,2010,15(8):477-480.
[12] Kumral A, Ozer E, Yilmaz O, et al. Neuroprotective effect of erythropoietin on hypoxic-ischemic brain injury in neonatal rats[J]. Biol Neonate,2003,83(3):224-228.
[13] 刘海樱,徐英美,陈凤展,等.重组人促红细胞生成素对缺氧缺血性脑损伤学习记忆能力的保护[J].中国临床康复,2006,10(14):59-61.
[14] Fauchere JC, Dame C, Vonthein R, et al. An approach to using recombinant erythropoietin for neuroprotection in very preterm infants[J]. Pediatrics,2008,122(2):375-382.
[15] He JS, Huang ZL, Yang H, et al. Early use of recombinant human erythropoietin promotes neurobehavioral development in preterm infants[J]. Zhongguo Dang Dai Er Ke Za Zhi,2008,10:586-588.
[16] Neubauer AP,Voss W, Wachtendorf M, et al. Erythropoietin Improves Neurodevelopmental Outcome of Extremely Preterm Infants[J]. Ann Neurol,2010,67(5):657-666.
[17] 罗小燕,周翔,韩静.注射重组人促红细胞生成素对早产儿贫血及神经系统作用的防治分析[J].实用心脑肺血管病杂志,2010,18(8):1039-1040.
[18] Zhu C, Kang W, Xu F, et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy[J]. Pediatrics,2009,124:e218-226.
[19] 郭晓燕,朱长连,程秀永,等.亚低温与促红细胞生成素联合治疗新生儿缺氧缺血性脑损伤的效果[J].实用儿科临床杂志,2008,23,(2):111-113.
[20] 罗海龙,金玉玲.IGF-1和EPO对新生大鼠海马源性神经干细胞分化是实验研究[J].齐齐哈尔医学院学报,2008,29(5):530-532.
-
总访问量
今日访问
在线人数
扫一扫，关注本刊微信公众号
版权所有 © 《中国儿童保健杂志》编辑部
技术支持：北京玛格泰克科技发展有限公司
技术支持：北京玛格泰克科技发展有限公司
/
| 〈 |
|
〉 |