摘要
维生素D缺乏的情况在世界各地普遍存在,近年来对于其引起相关疾病的研究取得了重要进展。维生素D具有重要的生理功能,其缺乏不仅在儿童期能导致许多骨性及非骨性疾病,而且成人期所患的心血管疾病、代谢性疾病、自身免疫病及癌症也与之密切相关。故为了足够引起对其缺乏的重视,预防相关疾病的发生,保证儿童及成人的身心健康,提高生活质量。本文就维生素D缺乏引起的相关疾病研究进展作一综述。
关键词
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参考文献
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[5] Bodnar LM, Simhan HN, Powers RW. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates[J]. J Nutr,2007,137(2):447-452.
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[7] Kimball S, Fuleihan Gel H, Vieth R. Vitamin D: a growing perspective[J]. Crit Rev Clin Lab Sci,2008,45(4):339-414.
[8] Bell DS. Protean manifestations of vitamin d deficiency, part 2: deficiency and its association with autoimmune disease, cancer, infection, asthma, dermopathies, insulin resistance, and type 2 diabetes[J]. South Med J,2011,104(5):335-339.
[9] Eyles DW, Feron F, Cui X, et al. Developmental vitamin D deficiency causes abnormal brain development[J]. Psychoneuroendocrinology,2009,34(S):247-257.
[10] Danescu LGLS, Levy J. Vitamin D and diabetes mellitus[J]. Endocrine,2009,35(1):11-17.
[11] Tishkoff DXNK, Holmberg KH, Dandu L, et al. Functional vitamin D receptor(VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility[J]. Endocrinology,2008,49(2):558-564.
[12] Maiya S, Sullivan I, Allgrove J, et al. Hypocalcaemia and vitamin D deficiency: an important, but preventable, cause of life-threatening infant heart failure[J]. Heart,2008,94(5):581-584.
[13] Ryan LM, Brandoli C, Freishtat RJ. Prevalence of vitamin D insufficiency in African American children with forearm fractures: a preliminary study[J]. J Pediatr Orthop,2010,30(2):106-109.
[14] Ginde AASR, Schwartz RS, Camargo CA Jr. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults[J]. J Am Geriatr Soc,2009,57(9):1595-1603.
[15] Tarcin OYD, Ozben B, Telli A. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects[J]. J Clin Endocrinol Metab,2009,94(10):4023-4030.
[16] Yavuz BED, Cil H, Ata N. Increased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins?[J]. Cardiovasc Drugs Ther,2009,23(4):295-299.
[17] Oh JWS, Felton SK, Bhandare S. 1,25(OH)2 vitamin D inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus[J]. Circulation,2009,120(8):687-698.
[18] Stechschulte SAKR, Federman DG. Vitamin D: bone and beyond, rationale and recommendations for supplementation[J]. Am J Med,2009,122(9):793-802.
[19] Chen P HP, Xie D, Qin Y. Meta-analysis of vitamin D, calcium and the prevention of breast cancer[J]. Breast Cancer Res Treat,2010,121(2):469-477.
[20] Edlich RFMS, Reddig JS, Gubler K. Revolutionary advances in the diagnosis of vitamin D deficiency[J]. J Environ Pathol Toxicol Oncol,2010,29(2):85-89.
[21] Edlich RFA, Chase ME, Brock CM. Modern concepts in the diagnosis and treatment of vitamin D deficiency and its clinical consequences[J]. J Environ Pathol Toxicol Oncol,2009,28(1):1-4.
[2] Hypponen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors[J]. Am J Clin Nutr,2007,85(3):860-886.
[3] Lips P. Vitamin D physiology[J]. Prog Biophys Mol Biol,2006,92(1):4-8.
[4] Bowden SA, Robinson RF, Carr R. Prevalence of vitamin D deficiency and insufficiency in children with osteopenia or osteoporosis referred to a pediatric metabolic bone clinic[J]. Pediatrics,2008,121(6):1585-1590.
[5] Bodnar LM, Simhan HN, Powers RW. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates[J]. J Nutr,2007,137(2):447-452.
[6] Reulecke BC, Erker CG, Fiedler BJ. Brain tumors in children: initial symptoms and their influence on the time span between symptom onset and diagnosis[J]. J Child Neurol,2008,23(2):178-183.
[7] Kimball S, Fuleihan Gel H, Vieth R. Vitamin D: a growing perspective[J]. Crit Rev Clin Lab Sci,2008,45(4):339-414.
[8] Bell DS. Protean manifestations of vitamin d deficiency, part 2: deficiency and its association with autoimmune disease, cancer, infection, asthma, dermopathies, insulin resistance, and type 2 diabetes[J]. South Med J,2011,104(5):335-339.
[9] Eyles DW, Feron F, Cui X, et al. Developmental vitamin D deficiency causes abnormal brain development[J]. Psychoneuroendocrinology,2009,34(S):247-257.
[10] Danescu LGLS, Levy J. Vitamin D and diabetes mellitus[J]. Endocrine,2009,35(1):11-17.
[11] Tishkoff DXNK, Holmberg KH, Dandu L, et al. Functional vitamin D receptor(VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility[J]. Endocrinology,2008,49(2):558-564.
[12] Maiya S, Sullivan I, Allgrove J, et al. Hypocalcaemia and vitamin D deficiency: an important, but preventable, cause of life-threatening infant heart failure[J]. Heart,2008,94(5):581-584.
[13] Ryan LM, Brandoli C, Freishtat RJ. Prevalence of vitamin D insufficiency in African American children with forearm fractures: a preliminary study[J]. J Pediatr Orthop,2010,30(2):106-109.
[14] Ginde AASR, Schwartz RS, Camargo CA Jr. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults[J]. J Am Geriatr Soc,2009,57(9):1595-1603.
[15] Tarcin OYD, Ozben B, Telli A. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects[J]. J Clin Endocrinol Metab,2009,94(10):4023-4030.
[16] Yavuz BED, Cil H, Ata N. Increased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins?[J]. Cardiovasc Drugs Ther,2009,23(4):295-299.
[17] Oh JWS, Felton SK, Bhandare S. 1,25(OH)2 vitamin D inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus[J]. Circulation,2009,120(8):687-698.
[18] Stechschulte SAKR, Federman DG. Vitamin D: bone and beyond, rationale and recommendations for supplementation[J]. Am J Med,2009,122(9):793-802.
[19] Chen P HP, Xie D, Qin Y. Meta-analysis of vitamin D, calcium and the prevention of breast cancer[J]. Breast Cancer Res Treat,2010,121(2):469-477.
[20] Edlich RFMS, Reddig JS, Gubler K. Revolutionary advances in the diagnosis of vitamin D deficiency[J]. J Environ Pathol Toxicol Oncol,2010,29(2):85-89.
[21] Edlich RFA, Chase ME, Brock CM. Modern concepts in the diagnosis and treatment of vitamin D deficiency and its clinical consequences[J]. J Environ Pathol Toxicol Oncol,2009,28(1):1-4.
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