类器官模型在儿童肥胖肠-肝-脂肪轴作用机制中的研究进展

doi:10.11852/zgetbjzz2025-0301

摘要/Abstract

摘要： 儿童肥胖及相关代谢性疾病的防治面临机制复杂、个体异质性显著等挑战,现有研究因缺乏精准模拟儿童代谢特征及多器官互作的体外模型而进展受限。随着类器官技术的突破,其在3D结构重建、遗传编辑及跨器官共培养中的优势,为体外研究提供了高度仿生的模型系统。本文聚焦肥胖儿童研究需求,综述肠道类器、肝脏类器官及脂肪类器官的构建策略与应用进展,并深入探讨模型标准化不足、代谢微环境模拟局限性及跨尺度数据整合困难等瓶颈问题,以期为肥胖相关代谢性疾病的机制研究及精准干预提供新的多维度研究策略和转化路径。

关键词: 类器官, 肥胖症, 儿童, 器官对话

Abstract: The prevention and treatment of childhood obesity and related metabolic disorders face significant challenges due to mechanistic complexity and marked individual heterogeneity.Current research is hindered by the lack of in vitro models capable of precisely simulating pediatric metabolic characteristics and multi-organ interactions.With breakthroughs in organoid technology, its advantages in 3D structural reconstruction, genetic editing, and cross-organ co-culture have established highly biomimetic model systems for in vitro research.This review focuses on the research demands of childhood obesity, systematically summarizing the construction strategies and application advances of intestinal organoids, hepatic organoid, and adipose organoid.It further addresses critical bottlenecks, including insufficient model standardization, limitations in metabolic microenvironment simulation, and challenges in cross-scale data integration, aiming to provide novel multi-dimensional research strategies and translational pathways for elucidating mechanisms and enabling precision interventions in obesity-related metabolic diseases.

Key words: organoids, obesity, children, inter-organ communication

中图分类号:

R179

王腾飞, 王泽芮, 王星云. 类器官模型在儿童肥胖肠-肝-脂肪轴作用机制中的研究进展[J]. 中国儿童保健杂志, 2025, 33(10): 1074-1078.

WANG Tengfei, WANG Zerui, WANG Xingyun. Progress on organoid models in the mechanism of the gut-liver- adipose axis in childhood obesity[J]. Chinese Journal of Child Health Care, 2025, 33(10): 1074-1078.

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