早期男性新生儿阴茎、睾丸发育与血清促卵泡刺激素、促黄体生成素、睾酮的相关性分析

doi:10.11852/zgetbjzz2024-0173

中国儿童保健杂志 ›› 2025, Vol. 33 ›› Issue (6): 660-663.DOI: 10.11852/zgetbjzz2024-0173

早期男性新生儿阴茎、睾丸发育与血清促卵泡刺激素、促黄体生成素、睾酮的相关性分析

牧丰苗¹, 简雪峰², 孟婕³, 姜志红²

1.河南科技大学临床医学院河南科技大学第一附属医院,河南洛阳 471003;
2.河南科技大学第一附属医院;
3.洛阳市妇幼保健院

收稿日期:2024-02-20 修回日期:2024-05-31 发布日期:2025-06-05 出版日期:2025-06-10
通讯作者: 姜志红,E-mail:3105515100@qq.com
作者简介:牧丰苗(1997—),女,在读硕士研究生,主要研究方向为儿童内分泌、遗传代谢性疾病。
基金资助:
河南省级科技研发计划联合基金项目(225200810054);河南省科技攻关计划项目(212102310780)

Correlation analysis of penile and testicular development with serum follicle stimulating hormone, luteinizing hormone, and testosterone in early male newborns

MU Fengmiao¹, JIAN Xuefeng², MENG Jie³, JIANG Zhihong²

1. College of Clinical Medicine of Henan University of Science and Technology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, China;
2. The First Affiliated Hospital of Henan University of Science and Technology;
3. Luoyang Maternal and Child Health Hospital

Received:2024-02-20 Revised:2024-05-31 Online:2025-06-10 Published:2025-06-05
Contact: JIANG Zhihong,E-mail:3105515100@qq.com

摘要/Abstract

摘要： 目的了解不同胎龄早期男性新生儿血清促卵泡刺激素(FSH)、促黄体生成素(LH)、睾酮(T)水平及其与阴茎长度、睾丸容积的关系,为男性性发育不良早期干预时机的选择及生育力保护提供依据。方法选取2022年1月—2023年2月河南科技大学第一附属医院新生儿病房的胎龄≥32周且病情平稳的50例早期男性新生儿为研究对象,按照胎龄将其分为早产儿组与足月儿组,测量阴茎长度及睾丸容积,采用化学发光免疫法测定血清FSH、LH、T水平,分析阴茎长度、睾丸容积与血清FSH、LH、T的关系。结果早产儿组与足月儿组血清FSH、LH、T水平比较,差异无统计学意义(P＞0.05)。两组新生儿血清FSH、LH水平与阴茎长度均呈正相关(早产儿组r=0.466、0.632,P＜0.05,足月儿组r=0.449、0.501,P＜0.05),患儿血清T水平与阴茎长度及睾丸容积均无相关性(P＞0.05)。足月儿组血清FSH、两组血清LH水平与睾丸容积均呈正相关(r=0.435、0.578、0.433,P＜0.05)。结论血清 FSH、LH、T水平与胎龄无关。FSH、LH对阴茎的生长发育有促进作用,LH对睾丸容积的增长具有促进作用,FSH仅在足月儿中对睾丸容积的增长具有促进作用。

关键词: 早期新生儿, 促性腺激素, 性激素, 阴茎, 睾丸

Abstract: Objective To investigate the serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) in early male neonates of different gestational ages and their relationships with penis length and testicular volume, so as to provide basis for the timing of early intervention in male sexual underdevelopment and fertility preservation. Methods From January 2022 to February 2023, 50 clinically stable early male neonates with a gestational age of ≥32 weeks admitted to the neonatal ward of the First Affiliated Hospital of Henan University of Science and Technology were selected into this study, and were divided into a preterm group and a term group based on their gestational age. Penis length and testicular volume were measured, and serum levels of FSH, LH, and T were tested using chemiluminescent immunoassay. The correlation of penis length and testicular volume with serum levels of FSH, LH, and T were analyzed. Results No significant differences were observed in serum levels of FSH, LH, and T between the preterm and term groups (P>0.05). Serum FSH and LH levels were positively correlated with penis length in both groups (preterm group: r=0.466, 0.632, P<0.05; term group: r=0.449, 0.501, P<0.05), while serum T levels were not significantly correlated with penis lengthand testicular volume in either group (P>0.05). Serum FSH level in the term group and serum LH level in both groups were positively correlated with (r=0.435, 0.578, 0.433, P<0.05). Conclusions Serum levels of FSH, LH, and T are not related to gestational age. FSH and LH promote the growth and development of the penis, and LH promotes testicular volume growth. Additionally, FSH is found to promote testicular volume growth only in term infants.

Key words: early newborns, gonadotropins, sex hormones, penile, testicular

中图分类号:

R722.1

牧丰苗, 简雪峰, 孟婕, 姜志红. 早期男性新生儿阴茎、睾丸发育与血清促卵泡刺激素、促黄体生成素、睾酮的相关性分析[J]. 中国儿童保健杂志, 2025, 33(6): 660-663.

MU Fengmiao, JIAN Xuefeng, MENG Jie, JIANG Zhihong. Correlation analysis of penile and testicular development with serum follicle stimulating hormone, luteinizing hormone, and testosterone in early male newborns[J]. Chinese Journal of Child Health Care, 2025, 33(6): 660-663.

参考文献

[1] Lanciotti L, Cofini M, Leonardi A, et al. Up-to-date review about minipuberty and overview on hypothalamic-pituitary-gonadal axis activation in fetal and neonatal life[J]. Frontiers in Endocrinology, 2018, 9: 410.
[2] Nordenström A.Potential impact of mini-puberty on fertility[J].Annales D′endocrinologie, 2022, 83(4):250-253.
[3] 寸跃爽,朱岷,郭淑娟,等.6月龄内健康男婴睾酮黄体生成素与促卵泡生成素血清浓度变化分析[J].中国实用儿科杂志, 2012,27(9):703-704,707.
Cun YS,Zhu M,Guo SJ, et al.Analysis of changes in serum concentrations of testosterone luteinizing hormone and follicle stimulating hormone in healthy male infants within 6 months of age[J].Chin J Pract Pediatr,2012,27(9): 703-704,707.(in Chinese)
[4] Lasiene K,Gasiliunas D,Juodziukyniene N,et al.Age-related morphological peculiarities of human testes[J]. Folia Morphologica,2021,80(1):122-126.
[5] Renault CH, Aksglaede L, Wøjdemann D, et al. Minipuberty of human infancy - A window of opportunity to evaluate hypogonadism and differences of sex development?[J]. Ann Pediatr Endocrinol Metab,2020,25(2): 84-91.
[6] 王瑞芳,董治亚,王伟,等.小青春期的抑制对雄性大鼠性发育的影响[J].上海交通大学学报(医学版), 2013, 33(11):1470-1474.
Wang RF,Dong ZY,Wang W, et al.Influence of hormone inhibition during minipuberty on sex development of male rats[J].J Shanghai Jiaotong Univ(Med Sci),2013,33(11): 1470-1474.(in Chinese)
[7] Kuiri-Hänninen T, Seuri R, Tyrväinen E, et al.Increased activity of the hypothalamic-pituitary-testicular axis in infancy results in increased androgen action in premature boys[J]. J Clin Endocrinol Metab, 2011, 96(1): 98-105.
[8] Lattuada M, Molinari S, Nicolosi ML, et al.Exaggerated mini-puberty in a preterm girl: A case report and review of literature[J].JPEM,2022,35(10): 1309-1315.
[9] Kareem AJ, Elusiyan JBE, Kareem AO. Stretched penile length and total serum testosterone in term male newborns[J]. Pan Afr Med J, 2020, 37:61.
[10] Mohamed MH, Abdou RM, Hamza MT, et al.Penile length and cord total and free testosterone in full term male Egyptian newborns[J].Egyptian Pediatric Association Gazette, 2015, 63(2): 58-62.
[11] Boehm U, Bouloux PM, Dattani MT, et al. Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment[J]. Nat Rev Endocrinol,2015, 11(9): 547-564.
[12] Becker M,Hesse V.Minipuberty: Why does it happen?[J]. Horm Res Paediatr, 2020, 93(2): 76-84.
[13] Tang Fui MN, Hoermann R, Wittert G, et al. Testicular volume and clinical correlates of hypothalamic-pituitary-testicular function:A cross-sectional study in obese men[J]. Asian J Androl, 2020, 22(4): 354.
[14] 赵彤,张祎俐,石鸿娇,等.超重、肥胖男童阴茎睾丸发育的相关性研究[J].医学研究杂志,2023,52(3): 44-48.
Zhao T,Zhang YL,Shi HJ, et al.Correlation study of penile testis development in overweight and obese boys[J].Journal of Medical Research, 2023, 52(3): 44-48.(in Chinese)
[15] Nguyen Hoai B, Hoang L, Tran D, et al. Ultrasonic testicular size of 24 440 adult Vietnamese men and the correlation with age and hormonal profiles[J].Andrologia, 2022, 54(2): e14333.

早期男性新生儿阴茎、睾丸发育与血清促卵泡刺激素、促黄体生成素、睾酮的相关性分析

Correlation analysis of penile and testicular development with serum follicle stimulating hormone, luteinizing hormone, and testosterone in early male newborns

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