基于全基因组关联研究数据分析肠道菌群与矮小症的因果关系

doi:10.11852/zgetbjzz2024-0581

中国儿童保健杂志 ›› 2024, Vol. 32 ›› Issue (11): 1201-1205.DOI: 10.11852/zgetbjzz2024-0581

基于全基因组关联研究数据分析肠道菌群与矮小症的因果关系

郑治民¹, 孙昊², 赵婷婷², 肖绪武^1,2

1.大连医科大学研究生院,辽宁大连 116000;
2.大连市妇女儿童医疗中心(集团)儿童保健科

收稿日期:2024-05-22 修回日期:2024-08-06 发布日期:2024-11-04 出版日期:2024-11-10
通讯作者: 肖绪武,E-mail:dlxiaoxw@163.com
作者简介:郑治民(1997-),男,博士研究生在读,主要研究方向为儿童保健与内分泌疾病。
基金资助:
大连市生命健康领域指导计划(2024年)

Causal relationship between gut microbiota and short stature based on genome-wide association study data

ZHENG Zhimin¹, SUN Hao², ZHAO Tingting², XIAO Xuwu^1,2

1. Graduate School, Dalian Medical University, Dalian, Liaoning 116000,China;
2. Department of Child Healthcare, Dalian Women and Children's Medical Center (Group)

Received:2024-05-22 Revised:2024-08-06 Online:2024-11-10 Published:2024-11-04
Contact: XIAO Xuwu, E-mail: dlxiaoxw@163.com

摘要/Abstract

摘要： 目的利用孟德尔随机化(MR)方法探究肠道菌群与矮小症之间的因果关系,为矮小症的临床诊疗提供参考。方法从MiBioGen联盟获得18 340个样本的属水平肠道菌群全基因组关联研究数据作为暴露组,从FinnGen联盟R9获取矮小症的全基因组关联研究数据作为结局组。采用逆方差加权法作为主要分析方法进行MR分析,并采用留一法、异质性检验、多效性检验等进行敏感性分析,反向MR以排除反向因果关系。结果肠道菌群中Prevotella9 (OR=1.76, 95%CI:1.10~2.82,P=0.018)、Alloprevotella (OR=1.82, 95%CI:1.22~2.72,P=0.003)、FamilyXIIIAD3011group (OR=1.86, 95%CI:1.04~3.31,P=0.036)与矮小症的发病呈正相关; Parasutterella (OR=0.58, 95%CI:0.37~0.92, P=0.020)、Clostridiumsensustricto1 (OR=0.50, 95%CI:0.25~0.99, P=0.045)、Roseburia(OR=0.48, 95%CI:0.26~0.89, P=0.020)与矮小症的发病呈负相关。结论肠道菌群中Prevotella9、Alloprevotella、FamilyXIIIAD3011group会增加矮小症的发生风险,Parasutterella、Clostridiumsensustricto1、Roseburia对矮小症的发生有保护作用。

关键词: 矮小症, 肠道菌群, 孟德尔随机化, 全基因组关联研究

Abstract: Objective To investigate the causal relationship between gut microbiota and short stature by genomewide Mendelian randomization(MR), in order to proride reference of clinical treatment of short statue. Methods Genus level gut microbiota genome-wide association study data of 18 340 samples was obtained from the MiBioGen as the exposure group, and genome-wide association study data of short stature were obtained from FinnGen R9 as the outcome group. The inverse variance weighting method was used as the main analysis method forMR analysis, and sensitivity analysis such as leave-one-out, heterogeneity test, and pleiotropy analysis were performed, reverse MR to rule out reverse causality. Results Prevotella9 (OR=1.76, 95%CI:1.10 - 2.82, P=0.018), Alloprevotella (OR=1.82, 95%CI:1.22 - 2.72, P=0.003), and FamilyXIIIAD3011group (OR=1.86, 95%CI:1.04 - 3.31, P=0.036) were positively correlated with the onset of short stature. Parasutterella (OR=0.58, 95%CI: 0.37 - 0.92, P=0.020), Clostridiumsensustricto1 (OR=0.50, 95%CI: 0.25 - 0.99, P=0.045), and Roseburia (OR=0.48, 95%CI:0.26 - 0.89, P=0.020) were negatively correlated with the onset of short stature. Conclusion Prevotella9, Alloprevotella, and FamilyXIIIAD3011group increase the risk of short stature, while Parasutterella, Clostridiumsensustricto1 and Roseburia have protective effects on the occurrence of short stature.

Key words: short stature, gut microbiota, mendelian randomization, genome-wide association study

中图分类号:

R725.8

郑治民, 孙昊, 赵婷婷, 肖绪武. 基于全基因组关联研究数据分析肠道菌群与矮小症的因果关系[J]. 中国儿童保健杂志, 2024, 32(11): 1201-1205.

ZHENG Zhimin, SUN Hao, ZHAO Tingting, XIAO Xuwu. Causal relationship between gut microbiota and short stature based on genome-wide association study data[J]. Chinese Journal of Child Health Care, 2024, 32(11): 1201-1205.

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基于全基因组关联研究数据分析肠道菌群与矮小症的因果关系

Causal relationship between gut microbiota and short stature based on genome-wide association study data

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