学龄儿童内脏脂肪面积与尿酸的相关性研究

doi:10.11852/zgetbjzz2021-1689

中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (12): 1276-1280.DOI: 10.11852/zgetbjzz2021-1689

学龄儿童内脏脂肪面积与尿酸的相关性研究

饶甲环^1*, 程红^2*, 闫银坤¹, 侯冬青², 赵小元², 朱忠信³, 郁兆仓⁴, 王宏健⁵, 高爱钰⁶, 米杰^1,2

1.国家儿童医学中心首都医科大学附属北京儿童医院儿童慢病管理中心,北京 100045;
2.首都儿科研究所流行病学研究室,北京 100020;
3.北京市密云区中小学卫生保健所;
4.北京市通州区中小学卫生保健所;
5.北京市房山区中小学卫生保健所;
6.北京市东城区中小学卫生保健所

收稿日期:2021-11-12 修回日期:2021-11-16 发布日期:2021-12-09
通讯作者: 米杰,E-mail:jiemi12@vip.sina.com
作者简介:饶甲环(1992-),男,广东人,博士研究生在读,主要研究方向为高尿酸血症及影响因素;程红(1969-),女,北京人,副主任技师,本科学历,主要研究方向为儿童慢性病综合性研究。注:^*共同第一作者。
基金资助:
国家自然科学基金(81973110);国家重点研发计划(2016YFC0900600,2016YFC0900602)

Correlation between visceral fat area and uric acid in school-age children

RAO Jia-huan^1*, CHENG Hong^2*, YAN Yin-kun, HOU Dong-qing, ZHAO Xiao-yuan, ZHU Zhong-xin, YU Zhao-cang, WANG Hong-jian, GAO Ai-yu, MI Jie

1^*Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China;
2^*Department of Epidemeiology,Capital Institute of Pediatric,Beijing 100020,China

Received:2021-11-12 Revised:2021-11-16 Published:2021-12-09
Contact: MI Jie, E-mail:jiemi12@vip.sina.com

摘要/Abstract

摘要： 目的探讨学龄儿童内脏脂肪面积与尿酸水平的关联,为预防儿童高尿酸血症(HUA)提供依据。方法研究对象来自“儿童青少年心血管与骨健康促进项目”于2019年11月—2020年1月进行的随访调查,最终纳入8～18岁儿童青少年10 609人进行分析。内脏脂肪面积(VFA)与各心血管代谢指标间的关联采用Spearman相关性分析。根据BMI和VFA诊断的肥胖与否将体型划分为4组,多因素Logistic回归分析不同肥胖类型与HUA的关联,并调整年龄、血压、血糖、血脂等潜在混杂因素。结果 VFA在生长发育进程中逐渐增加,并存在性别差异。男女童VFA与尿酸水平均呈正相关关系(r=0.399、0.375,P＜0.001),BMI评价的非超重、超重、肥胖组HUA患病率依次升高(男童依次为28.9%、43.5%和52.1%,女童依次为6.0%、15.9%和32.4%),VFA评价的肥胖组HUA患病率显著高于非肥胖组(男童:57.5% vs. 33.7%;女童:31.6% vs. 7.7%;P<0.001)。在调整了年龄、血压、血糖、血脂等混杂因素后,男童单纯腹型肥胖组HUA风险较非肥胖组增加1.70倍(OR=2.70, 95%CI: 1.36~5.35),女童混合型肥胖组的HUA风险较非肥胖组增加3.74倍(OR=4.74, 95%CI: 3.77~5.95)。结论儿童VFA与血尿酸水平密切相关,在健康体检中加入体成分分析可以早期发现儿童肥胖,对防控儿童HUA也具有重要意义。

关键词: 内脏脂肪面积, 尿酸, 肥胖, 儿童

Abstract: Objective To explore the correlation between visceral fat area (VFA) and uric acid level in school-age children, so as to provide reference for preventing hyperuricemia (HUA) of children. Methods Data were from school-based cardiovascular and bone health promotion program (SCVBH), and 10 609 children and adolescents aged 8 to 18 years were finally included for analysis. The correlation between VFA and cardiovascular metabolic parameters was analyzed by Spearman correlation analysis. The body type was divided into four groups according to obesity diagnosed by body mass index (BMI) and VFA. The association between different obesity types and HUA was analyzed by multivariate Logistic regression, and the potential confounding factors such as age, blood pressure, blood glucose and blood lipids were adjusted. Results VFA increased gradually with growth and development of children, and the gender difference was significant. VFA was positively correlated with uric acid level in boys and girls (r=0.399, 0.375, P＜0.001). The prevalence of HUA increased successively among the non-overweight, overweight and obesity group divided by BMI (28.9%, 43.5% and 52.1% for boys, 6.0%, 15.9% and 32.4% for girls, respectively). The prevalence of HUA in the obesity group evaluated by VFA was significantly higher than that in the non-overweight group (57.5% vs. 33.7% for boys, 31.6 % vs. 7.7 % for girls, P <0.001). After adjusting the confounding factors such as age, blood pressure, blood glucose and blood lipid, the ORs and 95%CIs of risk for HUA were 2.70 (95%CI: 1.36 - 5.35) in boyswith simple abdominal obesity.and 4.74 (95%CI:3.77 - 5.95) in girls with mixed obesity. Conclusions VFA is closely related to uric acid levels in children. Body composition analysis in health examination can early detect obesity in children, which is also of great significance for prevention and control of HUA in children.

Key words: visceral fat area, uric acid, obesity, children

中图分类号:

R723.14

饶甲环, 程红, 闫银坤, 侯冬青, 赵小元, 朱忠信, 郁兆仓, 王宏健, 高爱钰, 米杰. 学龄儿童内脏脂肪面积与尿酸的相关性研究[J]. 中国儿童保健杂志, 2021, 29(12): 1276-1280.

RAO Jia-huan, CHENG Hong, YAN Yin-kun, HOU Dong-qing, ZHAO Xiao-yuan, ZHU Zhong-xin, YU Zhao-cang, WANG Hong-jian, GAO Ai-yu, MI Jie. Correlation between visceral fat area and uric acid in school-age children[J]. Chinese Journal of Child Health Care, 2021, 29(12): 1276-1280.

参考文献

[1] Lee J, Lee JY, Lee JH, et al. Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study[J]. Arthritis Res Ther, 2015, 17(1): 79.
[2] Matsushita Y, Nakagawa T, Yamamoto S, et al. Associations of visceral and subcutaneous fat areas with the prevalence of metabolic risk factor clustering in 6,292 Japanese individuals: the hitachi health study[J]. Diabetes Care, 2010, 33(9): 2117-2119.
[3] 苏汇茹,程洪锋,梅英,等.内脏脂肪检测技术研究现状与进展[J].影像研究与医学应用,2021,5(5):3-4.
[4] 刘荣红,李国强,赵文增,等.人体成分分析仪在成年人正常体重人群脂肪肝中的应用[J].河北医科大学学报,2019,40(6):723-726.
[5] Genovesi S, Giussani M, Orlando A, et al. Prevention of Cardiovascular Diseases in Children and Adolescents[J]. High Blood Press Cardiovasc Prev, 2019, 26(3): 191-197.
[6] Zhou Z, Li K, Li X, et al. Independent and joint associations of body mass index, waist circumference, waist-height ratio and their changes with risks of hyperuricemia in middle-aged and older Chinese individuals: a population-based nationwide cohort study[J]. Nutr Metab (Lond), 2021, 18(1): 62.
[7] Ford ES, Li C, Cook S, et al. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents[J]. Circulation, 2007, 115(19): 2526-2532.
[8] 侯冬青,高爱钰,朱忠信,等.儿童青少年心血管与骨健康促进项目基线特征[J].中华预防医学杂志,2018,52(11):1117-1123.
[9] 胡亚美,江载芳.诸福棠实用儿科学[M].7版.北京:人民卫生出版社, 2002.
[10] 中华人民共和国国家卫生和计划生育委员会. WS/T 586-2018 学龄儿童青少年超重与肥胖筛查[M]. 北京: 中国标准出版社, 2018.
[11] 李林,朱小霞,戴宇翔,等.中国高尿酸血症相关疾病诊疗多学科专家共识[J].中华内科杂志,2017,56(3):235-248.
[12] Rospleszcz S, Dermyshi D, Müller-Peltzer K, et al. Association of serum uric acid with visceral, subcutaneous and hepatic fat quantified by magnetic resonance imaging[J]. Sci Rep, 2020, 10(1): 442.
[13] Zhang X, Zhu C, Gao J, et al. Gender difference in the relationship between serum uric acid reduction and improvement in body fat distribution after laparoscopic sleeve gastrectomy in Chinese obese patients: a 6-month follow-up[J]. Lipids Health Dis, 2018, 17(1): 288.
[14] Matsuzawa Y, Funahashi T, Nakamura T. The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism[J]. J Atheroscler Thromb, 2011, 18(8): 629-639.
[15] Lee DH, Park KS, Ahn S, et al. Comparison of abdominal visceral adipose tissue area measured by computed tomography with that estimated by bioelectrical impedance analysis method in Korean subjects[J]. Nutrients, 2015, 7(12): 10513-10524.
[16] Lee KK, Park HS, Yum KS. Cut-off values of visceral fat area and waist-to-height ratio: diagnostic criteria for obesity-related disorders in Korean children and adolescents[J]. Yonsei Med J, 2012, 53(1): 99-105.
[17] 前田和久,杨友竹.肥胖的诊断标准指南[J].日本医学介绍, 2004,25(3):99-101.
[18] 杨建雄,王健.6~21岁学生体成分的性别特点与年龄规律[J].体育科学,2005,25(8):67-70.
[19] Polcrova A, Pavlovska I, Maranhao Neto GA, et al. Visceral fat area and cardiometabolic risk: The Kardiovize study[J]. Obes Res Clin Pract, 2021, 15(4): 368-374.
[20] 李雪婷,刘卉,蒋琪,等.北京市海淀区6～15岁少儿体成分生长发育特征分析[J].中国儿童保健杂志,2017,25(10):998-1001.
[21] 杨乐,张宝,管石侠,等.不同性别不同年龄成年人体成分测量指标的检测分析[J].安徽医学,2019,40(11):1276-1279.
[22] Katzmarzyk PT, Heymsfield SB, Bouchard C. Clinical utility of visceral adipose tissue for the identification of cardiometabolic risk in white and African American adults[J]. Am J Clin Nutr, 2013, 97(3): 480-486.
[23] 李慧,刘小青,张冰,等.菊苣有效组分对高甘油三酯和高尿酸血症并高血糖大鼠脂代谢的影响[J].中西医结合学报,2008,6(2):157-162.
[24] Lurbe E, Torro MI, Alvarez-Pitti J, et al. Uric acid is linked to cardiometabolic risk factors in overweight and obese youths[J]. J Hypertens, 2018, 36(9): 1840-1846.
[25] Cao H. Adipocytokines in obesity and metabolic disease[J]. J Endocrinol, 2014, 220(2): 47-59.
[26] Shiina Y, Homma Y. Relationships between the visceral fat area on CT and coronary risk factor markers[J]. Intern Med, 2013, 52(16): 1775-1780.

学龄儿童内脏脂肪面积与尿酸的相关性研究

Correlation between visceral fat area and uric acid in school-age children

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