关键词: 特发性矮小症, rhGH, 来曲唑, 预测终身高

Abstract: Objective To study the efficacy of recombinant human growth hormone (rhGH) combined with letrozole on the improvement of the predicted final height in male children with adolescent idiopathic short stature (ISS). Methods Totally 60 male children diagnosed with adolescent idiopathic short stature admitted in Children's Hospital of Hebei Province from May 2015 to May 2019 were enrolled in this study and were divided into two groups by simple grouping method,with 30 cases in each group. The control group was treated with rhGH,while the experiment group was treated with rhGH and letrozole. Both groups were treated for one year. The improvement of physical development,growth rate,bone metabolism index and occurrence of adverse events were collected and analyzed. Results There were no significant differences in bone age,height and bone metabolism indexes between the two groups before treatment (P>0.05). After 1 year of treatment,the bone age and bone alkaline phosphatase(BALP) level of the experiment group were lower than those of the control group (t=6.537,9.290,P<0.05),and the levels of bone glaprotein(BGP),procollagen Ⅰ N-terminal peptide(PINP) and vitamin D of the experimental group were significantly higher than those of the control group (t=4.501,4.269,9.230,P<0.05). The predicted final height value was significantly higher in experiment group (t=2.833,P<0.05). There were no significant differences in growth rate and adverse reactions between the two groups (P<0.05). Conclusion Letrozole can improve the predicted final height of male children with adolescent idiopathic short stature.

Key words: idiopathic short stature, recombinant human growth hormone, letrozole, the predicted final height