关键词: 肿瘤坏死因子诱导蛋白样因子-2, 免疫球蛋白E, 哮喘

Abstract: Objective To analyze the effects of T tumor necrosis factor-induced protein 8 like-2(TIPE2) and immunoglobulin E(IgE) on the occurrence and development of asthma in children,in order to provide evidence for the diagnosis and treatment of children with asthma. Methods A total of 100 children with asthma treated in Zhengzhou Children's Hospital from January 2016 to December 2018 were enrolled in this study,and 98 children who took physical examinations at the same period were selected as control group.The expression levels of TIPE2 mRNA and protein,and the serum IgE level were tested in two groups of children,and the accuracy and sensitivity of various indicators were analyzed. Results The levels of TIPE2 mRNA and protein expression of mononuclear cells in patients with asthma were significantly lower than those in control group (t=15.165,21.265,P<0.001).The expression of IgE in asthma group was significantly higher than that in control group (t=138.139,P<0.001).The specificity and sensitivity of TIPE2 in combination with IgE for asthma diagnosis were significantly higher than those of only using TIPE2 or IgE for asthma diagnosis (χ²=14.624,13.455,18.000,14.559,P<0.001).After drug treatment,it was found that the expression level of TIPE2 in children with asthma increased significantly compared with that before treatment,while the expression of IgE decreased significantly (t=12.975,112.480,P<0.001). Conclusion s TIPE2 and IgE have important effects on the development of asthma children.The changes should be closely monitored during the treatment process,so as to provide new ideas for the diagnosis and treatment of asthma in children.

Key words: T tumor necrosis factor-induced protein 8 like-2, immunoglobulin E, asthma