关键词: 血氧饱和度, 临床评估, 先天性心脏病筛查

Abstract: Objective To evaluate the feasibility and reliability of screening for congenital heart disease (CHD) in newborn by using percutaneous oxygen saturation detection (POX) combined with clinical assessment. Methods Screening for CHD within 7 days after birth was performed in 62 000 newborns from August,2011 to December,2014 in Kunshan city.The suspected cases were finally diagnosed by Color Doppler echocardiography and were followed up regularly after discharge.Indexes including sensitivity,specificity,positive/negative predictive value and positive/negative likelihood ratio were calculated and compared. Results Among 62 000 newborns,539 cases were diagnosed with CHD.The sensitivity of pox screening combined with clinical assessment of congenital heart disease was 93% (95%CI:86.4%~95.4%),the specificity was 94.3%(95%CI:85.6%~96.0%),and the Youden index was 0.87. Conclusions POX combined with clinical evaluation for screening congenital heart disease is of high sensitivity and specificity.Cunent clinical assessment mainly use heart murmur as a screening tool,which is simple and accurate and is suitable for grassroots units to screen for newborns congenital heart disease screening.

Key words: pulse oximetry, clinical assessment, congenital heart disease screening