延边地区朝鲜族儿童维生素D受体基因Fok I位点多态性研究

doi:10.11852/zgetbjzz2015-23-04-05

中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (4): 351-353.DOI: 10.11852/zgetbjzz2015-23-04-05

延边地区朝鲜族儿童维生素D受体基因Fok I位点多态性研究

全京花¹,鲁衍强²,李瑛²,金京姬¹,宋锦霞¹

1 延边妇幼保健院,吉林延吉 133001;
2 上海靶向分子医学研究所,上海 200433

收稿日期:2014-11-03 发布日期:2015-04-10 出版日期:2015-04-10
通讯作者: 鲁衍强,E-mail:luyanqiang@genechina.com
作者简介:全京花(1962-),女,副主任医师,主要研究方向为儿童生长发育与营养。

Polymorphism of vitamin D receptor gene Fok I in the Korean children in Yanbian district

QUAN Jing-hua¹,LU Yan-qiang²,LI Ying²,JIN Jing-ji¹,SONG Jin-xia¹

1 Yanbian Maternal and Child Health Hospital,Yanji,Jilin 133001,China;
2 Shanghai Institute of Targeted Therapy and Molecular Medicine,Shanghai 200433,China

Received:2014-11-03 Online:2015-04-10 Published:2015-04-10
Contact: LU Yan-qiang,E-mail:luyanqiang@genechina.com

摘要/Abstract

摘要： 目的了解延边地区朝鲜族儿童维生素D受体(vitamin D receptor,VDR)基因Fok I位点的多态性分布特点,为进一步研究VDR基因多态性与骨代谢疾病的关系打下基础。方法应用荧光定量PCR方法,检测98名延边地区朝鲜族儿童的VDR基因Fok I位点多态性,分析该基因型和等位基因频率分布,并与已报道的其他民族、种族的数据进行比较。结果本研究人群VDR基因ff、Ff、FF基因型的分布频率分别为23%、40%、37%,该分布情况与国内云南阿昌族、甘肃东乡族以及国外美国黑人、尼日利亚人的差异具有统计学意义(P<0.05)。结论延边地区朝鲜族儿童VDR基因Fok I位点基因型和等位基因的频率分布特征有其自身的特点。

关键词: 维生素D受体, 基因多态性, 朝鲜族

Abstract: Objective To explore the polymorphism distribution of vitamin D receptor(VDR)gene Fok Ⅰin the Korean children in Yanbian Province for further study on relation between VDR gene polymorphisms and metabolic bone disease. Methods A total of 98 Korean children were recruited and collected oral epithelial cells.Genome DNA for fluorescence quantitative PCR to detect SNP of Fok Ⅰ were extracted.The results were compared with the distribution frequency of Fok Ⅰin other nations or races. Result The frequency of Fok Ⅰ( ff,Ff,FF ) in Korean children were 23%,40%,37% respectively,which were significant difference to Achangs,Dongxiang nationality,Americans and Nigerian (P<0.05). Conclusion Fok Ⅰ polymorphism distribution in Korean children exhibits its own characteristics.

Key words: vitamin D receptor, polymorphism, Korean

中图分类号:

R725

全京花,鲁衍强,李瑛,金京姬,宋锦霞. 延边地区朝鲜族儿童维生素D受体基因Fok I位点多态性研究[J]. 中国儿童保健杂志, 2015, 23(4): 351-353.

QUAN Jing-hua,LU Yan-qiang,LI Ying,JIN Jing-ji,SONG Jin-xia. Polymorphism of vitamin D receptor gene Fok I in the Korean children in Yanbian district[J]. journal1, 2015, 23(4): 351-353.

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延边地区朝鲜族儿童维生素D受体基因Fok I位点多态性研究

Polymorphism of vitamin D receptor gene Fok I in the Korean children in Yanbian district

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