学龄期高功能孤独症儿童脑白质微结构异常研究

doi:10.11852/zgetbjzz2014-22-05-12

中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (5): 484-487.DOI: 10.11852/zgetbjzz2014-22-05-12

学龄期高功能孤独症儿童脑白质微结构异常研究

张雯¹,静进¹,李咏梅²,曹牧青¹,康庄²,胡冰²,余美侨¹,叶晓芳¹,刘步云¹

1 中山大学公共卫生学院妇幼卫生系,广东广州 510080;
2 中山大学附属第三医院,广东广州 510630

收稿日期:2014-03-23 发布日期:2014-05-10 出版日期:2014-05-10
通讯作者: 静进,E-mail:jingjin@mail.sysu.edu.cn;李咏梅,E-mail:li-yongmei@163.com
作者简介:张雯(1987-),女,湖南人,在读硕士研究生,主要研究方向为临床儿童心理诊疗。
基金资助:
国家自然科学基金(81172687);国家自然科学基金(31100738)

Abnormal white matter microstructure study on high-functional autism of school age

ZHANG Wen¹,JING Jin¹,LI Yong-mei²,CAO Mu-qing¹,KANG Zhuang²,HU Bing²,YU Mei-qiao¹,YE Xiao-fang¹,LIU Bu-yun¹

1 Sun-yat sen University,Maternal and Child Health of Public Health School,Guangzhou,Guangdong 510080,China;
2 The 3rd Affiliated Hospital of Sun-yat sen University,Guangzhou,Guangdong 510630,China

Received:2014-03-23 Online:2014-05-10 Published:2014-05-10
Contact: JING Jin,E-mail:jingjin@mail.sysu.edu.cn;LI Yong-mei,E-mail:li-yongmei@163.com

摘要/Abstract

摘要： 目的通过扩散张量技术观察学龄期高功能孤独症儿童脑白质微结构的异常,探讨其可能的神经发育异常证据。方法对14例学龄期高功能孤独症男童(孤独症组:acdism spectrum disorders,ASDs组)及7名年龄、智力水平及利手均匹配的正常发育男童(正常对照组:TD组)行扩散张量成像观察,运用体素水平分析方法将两组的各向异性分数(fractional anisotropy,FA)及平均扩散水平(mean diffusivity,MD)进行对比分析。结果相对于TD组,ASDs组在左侧颞叶、左侧额叶、左侧枕叶以及海马、丘脑等皮质下核团的FA值升高,在左侧距状裂、双侧梭状回、右侧颞叶、右侧额叶、右侧枕叶以及左侧海马旁回、后扣带回、左侧舌回的MD值均降低。结论学龄期高功能孤独症儿童脑白质多个区域存在微结构的异常。

关键词: 高功能孤独症, 扩散张量成像, 体素水平分析

Abstract: Objective To examine the abnormal white matter microstructure of acdism spectrum disorders (ASDs) children of school age via Diffusion Tensor Imaging,so as to investigate the possible evidence of dysplasia of neurodevelopment. Methods 14 ASDs boys of school age and 7 age,IQ and handedness matched typically developing controls were examined by diffusion tensor imaging (DTI),the fractional anisotropy (FA) and mean diffusivity (MD) values were compared between two groups through voxel-based analysis. Results Compare to TD group,the FA value was increased in the left temporal gyrus,left frontal gyrus,left occipital gyrus,hippocampus and thalamus,and the MD value was decreased in the left calcarine fissure,bilateral fusiform gyrus,right temporal gyrus,right frontal gyrus,right occipital gyrus,left parahippocampus gyrus,posterior cingulate cortex and left lingual gyrus in ASDs group. Conclusion Abnormal white matter microstructure widely spread over the brain of high-functional autism of school age.

Key words: high-functional autism, diffusion tensor imaging, voxel-based analyze

中图分类号:

R749.94

张雯,静进,李咏梅,曹牧青,康庄,胡冰,余美侨,叶晓芳,刘步云. 学龄期高功能孤独症儿童脑白质微结构异常研究[J]. 中国儿童保健杂志, 2014, 22(5): 484-487.

ZHANG Wen,JING Jin,LI Yong-mei,CAO Mu-qing,KANG Zhuang,HU Bing,YU Mei-qiao,YE Xiao-fang,LIU Bu-yun. Abnormal white matter microstructure study on high-functional autism of school age[J]. journal1, 2014, 22(5): 484-487.

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学龄期高功能孤独症儿童脑白质微结构异常研究

Abnormal white matter microstructure study on high-functional autism of school age

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