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Diagnostic performance of functional near-infrared spectroscopy combined with behavioral assessment in attention-deficit hyperactivity disorder
- ZHANG Xi, REN Jiaojiao, GAO Hong, BAI Ruibei, WANG Zhaohui
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2025, 33(4):
402-408.
DOI: 10.11852/zgetbjzz2024-1153
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Objective To explore the prefrontal cortex (PFC) activation levels in children with attention deficit hyperactivity disorder (ADHD) during task states using functional near-infrared spectroscopy (fNIRS), and to evaluate the diagnostic value of combining PFC activation with behavioral assessments for distinguishing ADHD, so as to provide a basis for early diagnosis. Methods A total of 40 children diagnosed with ADHD and 30 healthy children undergoing routine health check-ups atthe Children's Health Department of Xi'an People's Hospital (Xi'an Fourth Hospital) from July 2023 to July 2024 were recruited. A 22-channel fNIRS device was used to measure changes in oxygenated hemoglobin (HbO2) concentration in the PFC during a verbal fluency task (VFT). The Conners Parent Symptom Questionnaire (PSQ) was administered, and correlations between PSQ scores and PFC HbO2 levels were analyzed. Receiver operating characteristic (ROC) curve analysis was performed to assess the sensitivity and specificity of combining HbO2 levels with PSQ scores for ADHD diagnosis. Results Compared to healthy children, ADHD children exhibited significantly lower HbO2 levels in the right dorsolateral prefrontal cortex (rDLPFC), left dorsolateral prefrontal cortex (lDLPFC), right frontopolar cortex (rFPC), medial prefrontal cortex (mFPC), and Brodmann area 8 (BA8) (Z=4.115, 2.363, 3.591, 2.578, 2.936, P<0.05). ADHD children also scored higher on the PSQ subscales for conduct problems, learning problems, impulsivity-hyperactivity, and hyperactivity index (Z=3.827, 4.065, 5.531, 4.827, P<0.05). Negative correlations were observed between learning problems and HbO2 levels in the rDLPFC, rFPC, and mFPC (r=-0.336,-0.412,-0.310, P<0.05), between impulsivity-hyperactivity and HbO2 levels in the mFPC (r=-0.382, P<0.05), and between the hyperactivity index and HbO2 levels in the rDLPFC, rFPC, mFPC, and BA8 (r=-0.393,-0.445,-0.431,-0.339, P<0.05). The area under the ROC curve (AUC) for the combined prediction of ADHD using HbO2 levels in the rDLPFC, lDLPFC, rFPC, lFPC, mFPC, and BA8 along with the hyperactivity index was 0.884, 0.877, 0.883, 0.900, 0.896, and 0.884, respectively, all of which were higher than the AUCs for HbO2 levels or the hyperactivity index alone. Conclusion Children with ADHD exhibit impaired PFC function, and the combination of PFC HbO2 levels and PSQ scores demonstrates significant diagnostic value for ADHD.