Objective To analyze the factors influencing the hospitalization time of preterm low birth weight infants, in order to provide a basis for shortening their hospital stay. Methods A total of 240 preterm low birth weight infants admitted to Zhongshan Hospital of Xiamen University from January 2019 to December 2020 were selected as study subjects. The hospitalization time was divided into two groups using a cutoff of 28 days, and the influencing factors on hospitalization time were analyzed. Results Univariate analysis showed that there were significant differences in feeding mode (χ2=15.105), dyspnea (χ2=37.604), feeding intolerance (abdominal distension χ2=19.288, vomiting χ2=27.539) between infants with hospitalization time ≥28 days and <28 days (P<0.05). Hospitalization time was positively correlated with weight loss (r=0.477), age at the lowest day of weight loss (r=0.390), age at regaining birth weight (r=0.454) and protein intake (r=0.396), and negatively correlated with the rate of weight gain (r=-0.655) and gestational age at birth (r=-0.454,P<0.001). Multivariate Logistic regression analysis revealed that the rate of weight gain (OR=0.23, 95%CI:0.103 - 0.536), breastfeeding (OR=0.75, 95%CI: 0.596 - 0.954), gestational age at birth (OR=0.23, 95%CI:0.113 - 0.536), and caloric intake (OR=0.85, 95% CI: 0.726 - 0.985) were positively associated with hospitalization time ≥28 days, while dyspnea (OR=2.83, 95%CI: 1.205 - 6.656) was a risk factor for hospitalization time ≥28 days (P<0.001). Conclusions The clinical characteristics of preterm low birth weight infants are distinctive, and attention should be given to changes in dyspnea indicators, daily weight gain rate, feeding mode, gestational age at birth and caloric intake. Relevant treatments should be implemented to reduce the hospitalization time of these infants.
Key words
premature low birth weight infants /
growth and development /
hospitalization time
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 单若冰,李跃,郭娜. 新生儿危重病例评分与临床危险指数评分预测极低出生体重儿死亡风险的比较[J]. 临床儿科杂志,2006,24(11):878-880.
Shan RB,Li Y,Guo N.Comparison of neonatal critical case score and clinical risk index score in predicting the death risk of very low birth weight infants[J].J Clin Pediatrics,2006,24(11): 878-880.(in Chinese)
[2] 中国新生儿重症监护室协作性质量改进研究协作组. 极低和超低出生体重儿重度脑室内出血发生情况及其影响因素多中心研究[J]. 中华儿科杂志, 2019, 57(4):258-264.
China Neonatal Intensive Care Unit Collaborative Quality Improvement Research Group.A multicenter study on the occurrence and influencing factors of severe intraventricular hemorrhage in very low and ultra-low birth weight infants[J].Chin J Pediatrics,2019,57(4):258-264.(in Chinese)
[3] 沈理笑.早产低出生体重儿常见的生长发育问题及处理[J].中国实用儿科杂志,2019,34(10):830-833.
Shen LX.Common growth and development problems and treatment of premature low birth weight infants[J].Chin J Practical Pediatrics,2019,34(10): 830-833.(in Chinese)
[4] Yeler O,Koseoglu MF.Performance prediction modeling of a premature baby incubator having modular thermoelectric heat pump system[J].App Thermal Engineering,2020,182(5):125-132.
[5] 王晓静, 马颖, 张雅丽. 妊娠晚期特发性羊水偏少孕妇羊水成分变化及对妊娠结局的影响[J].中国计划生育学杂志,2018,26(6):494-499.
Wang XJ, Ma Y, Zhang YL.Amniotic fluid composition changes in women with idiopathic oligohydramnios in the third trimester of pregnancy and its impact on pregnancy outcome[J].Chin J Family Planning, 2018,26(6): 494-499.(in Chinese)
[6] 王青青,杨丽君,董海,等.拉萨市某三级医院2017—2019年低出生体重影响因素分析[J].实用医院临床杂志,2021,18(3):40-44.
Wang QQ, Yang LJ, Dong H, et al. Analysis of influencing factors of low birth weight in a tertiary hospital in Lhasa from 2017 to 2019[J]. J Practical Hospital, 2021,18(3): 40-44.(in Chinese)
[7] Terri M, Patel RM, Roback JD, et al.Does red blood cell irradiation and/or anemia trigger intestinal injury in premature infants with birth weight≤1 250g? An observational birth cohort study[J]. BMC Pediatrics, 2018, 18(1):270-277.
[8] 金汉珍,黄德珉,官希吉.实用新生儿学[M].3版.北京:人民卫生出版社,2003.
Jin HZ, Huang D, Guan XJ. Practical neonatology[M]. 3rd Edition.Beijing: People's Health Publishing House, 2003.(in Chinese)
[9] 刘韬,仇小强,曾小云,等. 广西壮族地区孕妇早产的影响因素及早产与围生儿基本特征的关系[J]. 中国妇幼保健,2019,34(11):2596-2601.
Liu T,Qiu XQ, Zeng XY, et al. The influencing factors of premature delivery of pregnant women in Guangxi Zhuang Autonomous Region and the relationship between premature delivery and basic characteristics of perinatal infants[J].Chin Mat Chil Health Care, 2019, 34 (11): 2596-2601.(in Chinese)
[10] Ellenbogen J. Premature birth: The baby, the doctor and the psychoanalys[J]. Psychodynamic Practice, 2018.DOI:info:doi/10.1080/14753634.2017.1407665.
[11] 张娜,杨冲,王蓓.阻塞性睡眠呼吸暂停低通气综合征相关呼吸系统并发症研究进展[J].临床肺科杂志,2020,25(11):1758-1761.
Zhang N, Yang C, Wang B.Research progress on respiratory complications related to obstructive sleep apnea hypopnea syndrome[J]. J Clin Pulmonary Med, 2020,25 (11): 1758-1761.(in Chinese)
[12] 卢隽滢,卢红艳,常明,等. 不同无创通气模式在早产儿呼吸窘迫综合征撤机后的应用比较[J]. 实用医学杂志,2020,36(20):2797-2801.
Lu JY, Lu HY, Chang M, et al.Comparison of the application of different non-invasive ventilation modes in premature infants with respiratory distress syndrome after weaning[J].J Practical Med, 2020,36(20): 2797-2801.(in Chinese)
[13] 吴杰斌, 翟敬芳, 刘枭, 等. 无创高频与加温湿化高流量鼻导管通气在早产儿呼吸窘迫综合征序贯撤机的临床应用[J]. 中国小儿急救医学, 2021, 28(3):165-170.
Wu JB,Zhai JF, Liu X, et al Clinical application of non-invasive high-frequency and humidified high flow nasal catheter ventilation in sequential weaning of premature infants with respiratory distress syndrome[J].Chin J Pediatric Emergency Med, 2021,28 (3): 165-170.(in Chinese)
[14] Ardiansyah D, Nurhidayah I, Trisyany Y, et al. Effect of abdominal massage on feeding intolerance among premature baby with mechanical ventilati on in neonatal intensive care unit in indonesia[J].J Neonatal Nursing, 2020,2(4):125-128.
[15] Husain SA.Commentary: The end justifies the means: Employing a "modified" strategy for starnes palliation in a premature low birth weight infant with ebstein anomaly[J]. JTCVS Techniques, 2021,27(6):125.
[16] Ottolini KM, Andescavage N, Kapse K, et al. Improved brain growth and microstructural development in breast milk-fed very low birth weight premature infants[J]. Acta Paediatrica, 2020,109(8):125-132.