Analysis on the correlation of birth weight with physical development and glycolipid metabolism during infancy

WU Qiao-ling; YU Wen; GONG Chun-dan; ZHANG Dan; ZHAO Zheng-yan; PENG Yong-mei

doi:10.11852/zgetbjzz2018-0849

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (7) : 724-728. DOI: 10.11852/zgetbjzz2018-0849

Analysis on the correlation of birth weight with physical development and glycolipid metabolism during infancy

WU Qiao-ling¹, YU Wen¹, GONG Chun-dan², ZHANG Dan³, ZHAO Zheng-yan⁴, PENG Yong-mei^2,3

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Abstract

Objective To investigate the correlation of birth weight (BW) with children′s physical development and glycolipid metabolism during infancy,and to analyze the influencing factors of infant catch-up growth. Methods A total of 1 064 mother-child pairs were randomly recruited and the perinatal baseline information,anthropometric indexes and feeding data of children aged 0 to 18 months were recorded. The neonatal cord blood and the venous blood of 18-month-old children were tested for glycolipid metabolism indexes. Results BW of newborns presented significantly positive correlation with serum high sensitivity C-reactive protein (hCRP) but negative correlation with triglyceride (TG) ,and positive correlation between BW with lipoprotein a (Lpa) was found only in female infants (P<0.05). At 18 months old,negative correlation was found between BW with fasting glucose (GLU) in male and high density lipoprotein cholesterol (HDL-c) in female (P<0.05). Within 6 months old,significantly negative correlation between BW and children′s physical development was detected,and low birth weight (LBW) infants showed significantly more physical catch-up growth (P<0.01). Lower BW,mashed and fluid supplementary food were found to be promoting factors of body mass index Z score(BMIZ)catch-up growth within 6 months old,while paternal hypertension,eating slowly,higher fish-species consumption frequency and higher family income were shown to be weakening factors for BMIZ catch-up growth. Conclusions Extremely high or low of BW is likely to have adverse effects on glycolipid metabolism. Significant higher BMIZ catch-up growth in LBW infants within 6 months old may increase the risk of metabolic syndrome (MS) in adulthood

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infants / birth weight / physical growth / glycolipid metabolism / metabolic syndrome

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WU Qiao-ling, YU Wen, GONG Chun-dan, ZHANG Dan, ZHAO Zheng-yan, PENG Yong-mei. Analysis on the correlation of birth weight with physical development and glycolipid metabolism during infancy[J]. Chinese Journal of Child Health Care. 2019, 27(7): 724-728 https://doi.org/10.11852/zgetbjzz2018-0849

References

[1] Stansfield BK,Fain ME,Bhatia J,et al.Nonlinear relationship between birth weight and visceral fat in adolescents[J].J Pediatr,2016,174:185-192.
[2] Tam CH,Wang Y,Luan J,et al.Non-linear relationship between birthweight and cardiometabolic risk factors in Chinese adolescents and adults[J].Diabet Med,2015,32(2):220-225.
[3] Heindel JJ,Vandenberg LN.Developmental origins of health and disease:a paradigm for understanding disease cause and prevention[J].Curr Opin Pediatr,2015,27(2):248-253.
[4] de Jong M,Lafeber HN,Cranendonk A,et al.Components of the metabolic syndrome in early childhood in very-low-birth-weight infants[J].Horm Res Paediatr,2014,81(1):43-49.
[5] Santangeli L,Sattar N,Huda SS.Impact of maternal obesity on perinatal and childhood outcomes[J].Best Pract Res Clin Obstet Gynaecol 2015;29:438-448.
[6] Tang Q,Li X,Song P,et al.Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and pre-diabetes screening:Developments in research and prospects for the future[J].Drug Discov Ther,2015,9(6):380-385.
[7] Pan HC,Sheu WH,Lee WJ,et al.Coronary severity score and C-reactive protein predict major adverse cardiovascular events in patients with stable coronary artery disease (from the Taichung CAD Study)[J].Clin Chim Acta,2015,445:93-100.
[8] Azadbakht L,Kelishadi R,Saraf-Bank S,et al.The association of birth weight with cardiovascular risk factors and mental problems among Iranian school-aged children:the CASPIAN-III study [J].Nutrition,2014,30(2):150-158.
[9] Mullett MD,Cottrell L,Lilly C,et al.Association between birth characteristics and coronary disease risk factors among fifth graders[J].J Pediatr,2014,164(1):78-82.
[10] Hou RL,Jin WY,Chen XY,et al.Cord blood C-peptide,insulin,HbA1c,and lipids levels in small-and large-for-gestational-age newborns[J].Med Sci Monit,2014,20:2097-2105.
[11] Finkielstain GP,Lui JC,Baron J.Catch-up growth:cellular and molecular mechanisms [J].World Rev Nutr Diet,2013,106:100-104.
[12] Brown LD,Hay WJ.Impact of placental insufficiency on fetal skeletal muscle growth[J].Mol Cell Endocrinol,2016,435:69-77.
[13] Kelishadi R,Haghdoost AA,Jamshidi F,et al.Low birthweight or rapid catch-up growth:which is more associated with cardiovascular disease and its risk factors in later life? A systematic review and cryptanalysis[J].Paediatr Int Child Health,2015,35(2):110-123.
[14] de Arriba A,Dominguez M,Labarta JI,et al.Metabolic syndrome and endothelial dysfunction in a population born small for gestational age relationship to growth and Gh therapy[J].Pediatr Endocrinol Rev,2013,10(3):297-307.
[15] Fujita Y,Kouda K,Nakamura H,et al.Association of rapid weight gain during early childhood with cardiovascular risk factors in Japanese adolescents[J].J Epidemiol,2013,23:103-108.
[16] Zhu B,Haruyama Y,Muto T,et al.Association between eating speed and metabolic syndrome in a three-year population-based cohort study[J].J Epidemiol,2015,25(4):332-336.
[17] Lee S,Ko BJ,GongY,etal.Self-reported eating speed in relation to non-alcoholic fatty liver disease in adults[J].Eur J Nutr,2015,55(1):327-333.
[18] Hermans R C,Hermsen S,Robinson E,et al.The effect of real-time vibrotactilefeedback delivered through an augmented fork on eating rate,satiation,and food intake[J].Appetite,2017,113:7-13.
[19] Meng L,Liang Y,Liu J,et al.Prevalence and risk factors of hypertension based on repeated measurements in Chinese children and adolescents[J].Blood Press,2013,22(1):59-64.
[20] Hillman S,Peebles DM,Williams DJ.Paternal metabolic and cardiovascular risk factors for fetal growth restriction:a case-control study[J].Diabetes Care,2013,36(6):1675-1680.
[21] Kakinami L,Gauvin L,Barnett T A,et al.Trying to lose weight:the association of income and age to weight-loss strategies in the U.S[J].Am J Prev Med,2014,46(6):585-592.
[22] 翟屹,夏代提古丽·苏拉衣曼,李伟荣,等.家庭社会经济地位与儿童超重肥胖的关系[J].中华预防医学杂志,2013(10):945-948.