Abstract: Objective To understand the difference of the neurodevelopment and mental development between human immunodeficiency virus (HIV) exposed infants and HIV non-exposed,in order to provide reference for making up intervention measures to improve their health. Methods One year old infants born from Jul.2010 to Nov.2013 by women with HIV positive were selected as exposure group,and matching the same age infants with HIV negative mothers.The Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-Ⅲ) was used to assess comprehensive development of the sampled babies.A questionnaire survey was conducted on infant care givers. Results Except for language scale,the HIV exposed group got lower scores in cognitive scale,motor scale,social-emotion scale and adaptive behavior scale (94.09,96.27,79.60 and 86.09) than the non-exposed group(101.36,98.52,93.86 and 92.89,P<0.01).The percentages of infants with social-emotion scale and adaptive behavior scale below edge in exposure group (45.45% and 38.64%) were significantly higher than those of the non-exposure group (22.73% and 15.91%). Conclusion HIV exposure may affect neurodevelopment and mental development of infant,and the comprehensive health care,especially neurodevelopment and mental care,need to be improved for HIV exposed children.

Key words: human immunodeficiency virus exposure, infant development, Bayley-Ⅲ

摘要： 目的 了解人类免疫缺陷病毒(HIV)感染妇女所生婴儿的神经心理发育情况,为制定该特殊群体儿童健康改善措施提供依据。方法 选取2010年7月-2013年11月期间昆明市HIV感染妇女所生的1岁婴儿为研究对象,按条件配对,利用BayleyⅢ婴幼儿发育量表对婴儿进行神经心理发育测评,问卷收集有关信息。结果 暴露组婴儿除了语言量表外,认知、运动、社会情绪、适应性行为量表得分(分别是94.09、96.27、79.60和86.09)均明显低于非暴露组的得分(101.36、98.52、93.86和92.89,P<0.01),暴露组婴儿社会情绪、适应性行为量表得分低于边缘及以下水平的比例(45.45%和38.64%),显著高于非暴露组婴儿(22.73%和15.91%)。结论 HIV感染对婴儿神经心理发育影响明显,应加强对HIV感染妇女所生婴儿神经心理发育的保健指导工作。

关键词: HIV暴露, 婴儿发育, BayleyⅢ婴幼儿发育量表