doi:10.11852/zgetbjzz2016-24-04-13

Abstract

摘要： Kisspeptin是KiSS-1基因编码的一组多肽激素,与受体GPR54一起组成KiSS-1/GPR54系统,参与下丘脑-垂体-性腺轴功能的调节,并在青春期启动和促性腺素释放过程中发挥非常重要的作用。本文主要对KiSS-1/GPR54系统的分子结构,信号转导途径及对性腺轴功能的调节进行介绍。

关键词: kisspeptin, GPR54, 下丘脑-垂体-性腺轴, 性早熟

CLC Number:

R179

宋薇,陈冠宜综述, 薛江审校. KiSS-1/GPR54系统对性腺轴的作用[J]. 中国儿童保健杂志, 2016, 24(4): 384-386.

[1] Lee JH,Miele ME,Hicks DJ,et al.KiSS-1,a novel human malignant melanoma metastasis-suppressor gene[J].J Natl Cancer Inst,1996,88(23):1731-1737.
[2] West A,Vojta PJ,Welch DR,et al.Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1)[J].Genomics,1998,54(1):145-148.
[3] Ohtaki T,Shintani Y,Honda S,et al.Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor[J].Nature,2001,411(6837):613-617.
[4] Muir AI,Chamberlain L,Elshourbagy NA,et al.AXOR12,a novel human G protein-coupled receptor,activated by the peptide KiSS-1[J].J Biol Chem,2001,276(31):28969-28975.
[5] Clarkson J,D'anglemont DE,Tassigny X,et al.Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge[J].J Neurosci,2008,28(35):8691-8697.
[6] Seminara SB,Messager S,Chatzidaki EE,et al.The GPR54 gene as a regulator of puberty[J].N Engl J Med,2003,349(17):1614-1627.
[7] George JT,Seminara SB.Kisspeptin and the hypothalamic control of reproduction:lessons from the human[J].Endocrinology,2012,153(11):5130-5136.
[8] Smith JT,Rao A,Pereira A,et al.kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge:evidence that gonadotropes are not direct targets of kisspeptin in vivo[J].Endocrinology,2008,149(4):1951-1959.
[9] Robertson JL,Clifton DK,Delaiglesia HO,et al.Circadian regulation of kiss1 neurons:implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge[J].Endocrinology,2009,150(8):3664-3671.
[10] Gottsch ML,Navarro VM,Zhao Z,et al.Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways[J].J Neurosci,2009,29(29):9390-9395.
[11] Kauffman AS.Sexual differentiation and the Kiss1 system:hormonal and developmental considerations[J].Peptides,2009,30(1):83-93.
[12] Atkin SD,Owen BM,Bookout AL,et al.Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus[J].Mol Endocrinol,2013,27(4):598-605.
[13] Navarro VM,Castellano JM,Fernandez-fernandez R,et al.Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor,GPR54,in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide[J].Endocrinology,2004,145(10):4565-4574.
[14] Louis GW,Greenwald-yarnell M,Phillips R,et al.Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis[J].Endocrinology,2011,152(6):2302-2310.
[15] Luque RM,Kieman RD,Tena-sempere M.Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors:analyses using mouse models and a cell line[J].Endocrinology,2007,148(10):4601-4611.
[16] Qiu X,Dowling AR,Marino JS,et al.Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells[J].Endocrinology,2013,154(3):1337-1348.
[17] Luan X,Zhou Y,Wang W,et al.Association study of the polymorphisms in the Kiss-1 gene with central precocious puberty in Chinese girls[J].Eur J Endocrinol,2007,157(1):113-118.
[18] Teles MG,Bianco SD,Brito VN,et al.A GPR54-activating mutation in a patient with central precocious puberty[J].N Engl J Med,2008,358(7):709-715.
[19] De vries L,Shtaif B,Phillip M,et al.Kisspeptin serum levels in girls with central precocious puberty[J].Clin Endocrinol (Oxf),2009,71(4):524-528.
[20] Herreboudt AM,Kyle VR,Lawrence J,et al.Kiss1 mutant placentas show normal structure and function in the mouse[J].Placenta,2015,36(1):52-58.

KiSS-1/GPR54系统对性腺轴的作用

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