Abstract: Objective To investigate impact of the core symptoms of autism spectrum disorders(ASD) on healthrelated quality of life（HRQoL） in children. Methods The children with ASD who participated in structured training class in April to October,2014 in the Children's Hospital of Chongqing Medical University were researched.Core symptoms questionnaire and the Scale of Life Quality( PedsQLTM 4.0)，were used to analyze the relationship between the core symptoms and the HRQoL of ASD. 〓〖WT5"HZ〗Results〖WT5"BZ〗〓1) The relationships of patterns of restricted or repetitive interests and behaviors with PedsQL total score,emotional function,social function were negatively correlated （r=-0.503，-0.600，-0.474）,there were statistically significant （P<0.01），no significant correlation was found with physiological function,school performance.There was no significant correlation in social barriers associated with HRQoL of children with ASD.2)In mild patterns of restricted or repetitive interests and behaviors of children with ASD，the PedsQL total score,physical function,emotional function,social function and school function were higher than severe patterns of restricted or repetitive interests and behaviors of children with ASD,differences in emotional function,social function were statistically significant（P<0.05）.Overall quality of life,physical function,school performance differences were not statistically significant. Conclusions 1)The children with ASD is poor HRQoL.HRQoL relate to patterns of restricted or repetitive interests and behaviors.2)The more serious of patterns of restricted or repetitive interests and behaviors of children with ASD,the more worse HRQoL of children with ASD had.Improving patterns of repetitive interests and behaviors of children with ASD is will help improve HRQoL of children with ASD.

Key words: autism spectrum disorder, core symptoms, behavior, social interaction, healthrelated quality of life

摘要： 目的 了解孤独症谱系障碍(ASD)的核心症状对患儿健康相关生命质量(HRQoL)的影响。方法 以2014年4-10月在重医附属儿童医院儿保科参加结构化训练的患儿为研究对象，采用自设孤独症核心症状问卷及 PedsQL^TM 4.0生命质量家长报告，分析 ASD核心症状与PedsQoL总体及各维度的关系。结果 1)核心症状中重复刻板行为及狭隘兴趣与PedsQoL总分、情感及社交功能呈负相关(r=-0.503，-0.600，-0.474，P均<0.01)，与生理及学校功能无显著相关;社交沟通及社会互动障碍与ASD患儿PedsQoL总分及各功能区均无显著相关。2)轻度重复刻板行为及狭隘兴趣的ASD患儿在PedsQL总得分及各功能区得分均高于重度的患儿，其中在情感及社交功能方面的差异有统计学意义(P<0.05)，总体生命质量、生理功能、学校功能差异无统计学意义。结论 ASD患儿HRQoL与重复刻板行为及狭隘兴趣有关，重复刻板行为及狭隘兴趣症状越重，ASD患儿的HRQoL越差。改善孤独症患儿重复刻板行为及狭隘兴趣，将有助于提高孤独症患儿HRQoL。

关键词: 孤独症谱系障碍, 核心症状, 行为, 社交, 健康相关生命质量